Fig. 1

Joint analysis for associations of ideal cardiovascular health metrics categories and genetic risk groups with risk of incident heart failure in CKB and UKB. ICVHMs, ideal cardiovascular health metrics. The categories were defined according to ICVHMs as favorable (6 to 8), intermediate (3 to 5), and unfavorable (0 to 2). PRS, polygenic risk score. The genetic risk categories were defined according to a weighted PRS as low (lowest tertile), intermediate (intermediate tertile), and high (highest tertile). The numbers above the curves represent the hazard ratios and the 95% confidence intervals. Cox proportional hazard regression in CKB adjusted for sex, education, marital status, and family histories of heart attack or stroke at baseline and stratified jointly by study area and age at baseline in the 5-year interval. Cox proportional hazard regression in UKB adjusted for sex, education, marital status, and socioeconomic status and first 20 principal components of ancestry and stratified jointly by age at baseline in the 5-year interval. HR, hazard ratio; CI, confidence interval