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Table 3 Risk of incident heart failure according to ideal cardiovascular health metrics categories within each genetic risk category in CKB and UKB

From: Modification effect of ideal cardiovascular health metrics on genetic association with incident heart failure in the China Kadoorie Biobank and the UK Biobank

ICVHMs and PRS categories

Cases/1000 PYs

HR (95% CI)a

P valueb

Absolute risk over 10 years (95% CI)

Absolute risk reduction over 10 years

CKB

 High genetic riskc

  ICVHMsd per point

 

0.86 (0.79, 0.94)

0.003

  

  Unfavorable ICVHMs (n = 725)

3.04

1.00

 

2.50% (1.53, 4.06)

 

  Intermediate ICVHMs (n = 20,795)

1.77

0.64 (0.42, 0.97)

0.036

1.67% (1.50, 1.86)

0.83%

  Favorable ICVHMs (n = 8108)

0.64

0.48 (0.30, 0.77)

0.002

0.80% (0.63, 1.01)

1.70%

 Intermediate genetic risk

  ICVHMs per point

 

0.82 (0.74, 0.91)

0.001

  

  Unfavorable ICVHMs (n = 810)

2.77

1.00

 

2.54% (1.48, 4.33)

 

  Intermediate ICVHMs (n = 23,889)

1.75

0.71 (0.41, 1.21)

0.205

1.58% (1.40, 1.80)

0.96%

  Favorable ICVHMs (n = 9481)

0.65

0.41 (0.22, 0.77)

0.005

0.51% (0.36, 0.72)

2.03%

 Low genetic risk

  ICVHMs per point

 

0.87 (0.80, 0.94)

0.037

  

  Unfavorable ICVHMs (n = 794)

2.27

1.00

 

2.25% (1.44, 3.52)

 

  Intermediate ICVHMs (n = 22,534)

1.50

0.91 (0.59, 1.41)

0.674

1.48% (1.34, 1.64)

0.77%

  Favorable ICVHMs (n = 8878)

0.79

0.71 (0.44, 1.15)

0.163

0.68% (0.54, 0.86)

1.57%

UKB

 High genetic risk

  ICVHMs per point

 

0.81 (0.76, 0.85)

<0.001

  

  Unfavorable ICVHMs (n = 4298)

2.77

1.00

 

2.74% (2.23, 3.35)

 

  Intermediate ICVHMs (n = 71,430)

1.19

0.47 (0.38, 0.58)

<0.001

1.13% (1.05, 1.22)

1.61%

  Favorable ICVHMs (n = 22,979)

0.75

0.37 (0.28, 0.47)

<0.001

0.68% (0.58, 0.80)

2.06%

 Intermediate genetic risk

  ICVHMs per point

 

0.78 (0.74, 0.82)

<0.001

  

  Unfavorable ICVHMs (n = 5166)

2.69

1.00

 

2.51% (2.09, 3.01)

 

  Intermediate ICVHMs (n = 84,540)

1.17

0.48 (0.39, 0.58)

<0.001

1.11% (1.04, 1.19)

1.40%

  Favorable ICVHMs (n = 27,462)

0.62

0.32 (0.25, 0.41)

<0.001

0.57% (0.48, 0.67)

1.94%

 Low genetic risk

  ICVHMs per point

 

0.80 (0.77, 0.85)

<0.001

  

  Unfavorable ICVHMs (n = 5030)

2.36

1.00

 

2.18% (1.79, 2.65)

 

  Intermediate ICVHMs (n = 86,207)

1.09

0.51 (0.41, 0.63)

<0.001

1.04% (0.97, 1.12)

1.14%

  Favorable ICVHMs (n = 28,670)

0.59

0.34 (0.26, 0.44)

<0.001

0.57% (0.48, 0.69)

1.61%

  1. aCox proportional hazard regression in the CKB adjusted for sex, education, marital status, and family histories of heart attack or stroke at baseline and stratified jointly by study area and age at baseline in the 5-year interval. Cox proportional hazard regression in the UKB adjusted for sex, education, marital status, and socioeconomic status and first 20 principal components of ancestry and stratified jointly by age at baseline in the 5-year interval. HR, hazard ratio; CI, confidence interval
  2. bP value for trend calculated treating the three scores as continuous variables
  3. cGenetic risk categories were defined according to a weighted polygenic risk score as low (lowest tertile), intermediate (intermediate tertile), and high (highest tertile)
  4. dICVHMs, ideal cardiovascular health metrics. The categories defined according to ideal cardiovascular health metrics as favorable (6 to 8), intermediate (3 to 5), and unfavorable (0 to 2)
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BMC Medicine

ISSN: 1741-7015

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