Fig. 2

Identification of the methylated DNA ITGA4 and bacterial Fn and Pa for CRC detection. A, B Methylation levels (A) and ROC curves along with the corresponding AUCs (B) of the 7 candidate methylated DNA markers in 48 CRC and adjacent normal tissues. C, D Methylation levels (C) and ROC curves and the corresponding AUCs (D) of the 3 selected methylated DNA markers in fecal samples collected from 48 CRC and 40 healthy subjects. E, F Relative abundance (E) and ROC curves along with the corresponding AUCs (F) of the 5 candidate bacterial markers in fecal samples collected from 48 CRC and 40 healthy subjects. NS, nonsignificant, ** P < 0.01, ***P < 0.001