Table 1 Characteristics of patients, according to cardiometabolic disease status at baseline
| Â | No cardiometabolic disease at baseline | With cardiometabolic disease at baseline | All patients | ||||||
|---|---|---|---|---|---|---|---|---|---|
Myocardial infarction | Diabetes | Stroke | Myocardial infarction and diabetes | Myocardial infarction and stroke | Stroke and diabetes | Myocardial infarction, stroke and diabetes | |||
No. of patients (% women) | 1,861,821 (52) | 33,581 (30) | 71,399 (47) | 25,136 (53) | 7206 (30) | 2901 (36) | 4753 (46) | 934 (33) | 2,007,731 (51) |
Baseline characteristics | |||||||||
 Mean (SD) age (years) | 50.0 (17.0) | 71.4 (11.7) | 64.5 (14.3) | 73.7 (13.5) | 71.3 (10.5) | 76.8 (10.2) | 73.8 (10.6) | 75.1 (9.1) | 51.4 (17.5) |
 % White ethnicity (n) | 96 (579,570) | 98 (15,845) | 94 (27,511) | 98 (11,538) | 95 (3004) | 99 (1407) | 95 (2003) | 97 (417) | 96 (641,295) |
  [N] | [601,722] | [16,150] | [29,260] | [11,743] | [3154] | [1426] | [2100] | [432] | [665,987] |
 % Hypertension (n) | 34 (598,162) | 61 (20,232) | 65 (46,582) | 69 (17,094) | 68 (4,864) | 68 (1959) | 76 (3599) | 72 (669) | 37 (693,161) |
  [N] | [1,736,780] | [33,443] | [71,180] | [24,931] | [7199] | [2887] | [4736] | [929] | [1,882,085] |
 % Dyslipidaemia (n) | 50 (438,350) | 18 (4802) | 18 (10,623) | 25 (4289) | 13 (772) | 18 (373) | 16 (588) | 14 (101) | 46 (459,898) |
  [N] | [876,937] | [27,191] | [59,942] | [16,842] | [6040] | [2124] | [3647] | [724] | [993,447] |
 % Most deprived fifth (n) | 14 (258,571) | 17 (5607) | 18 (12,535) | 17 (4322) | 19 (1400) | 18 (530) | 20 (971) | 22 (201) | 14 (284,137) |
  [N] | [1,857,578] | [33,500] | [71,387] | [25,087] | [7196] | [2897] | [4746] | [934] | [2,003,225] |
 % BMI ≥30 kg/m2 (n) | 16 (194,941) | 20 (5451) | 42 (25,661) | 18 (3153) | 39 (2510) | 17 (393) | 36 (1417) | 35 (284) | 17 (233,809) |
  [N] | [1,235,911] | [27,421] | [61,687] | [17,934] | [6414] | [2244] | [3911] | [816] | [1,356,338] |
 % Ever smokers (n) | 43 (585,436) | 63 (18,309) | 48 (29,466) | 50 (9,863) | 61 (3957) | 59 (1428) | 51 (2083) | 58 (486) | 44 (651,028) |
  [N] | [1,351,139] | [29,268] | [61,711] | [19,904] | [6475] | [2437] | [4055] | [833] | [1,475,822] |
 No. with other comorbidities, % (n) | |||||||||
  None | 52 (964,906) | 21 (7068) | 30 (21,397) | 17 (4283) | 16 (1139) | 9 (253) | 14 (664) | 7 (64) | 50 (999,774) |
  One | 26 (491,284) | 24 (8233) | 28 (19,673) | 24 (5983) | 21 (1527) | 16 (479) | 22 (1038) | 14 (132) | 26 (528,349) |
  Two | 12 (227,813) | 20 (6817) | 19 (13,319) | 21 (5344) | 21 (1493) | 18 (536) | 22 (1046) | 20 (187) | 13 (256,.555) |
  Three | 6 (102,475) | 14 (4784) | 11 (8014) | 16 (4101) | 16 (1176) | 19 (562) | 17 (787) | 18 (170) | 6 (122,069) |
  Four | 2 (44,217) | 9 (3092) | 6 (4580) | 10 (2553) | 10 (757) | 15 (430) | 11 (505) | 16 (146) | 3 (56,280) |
  Five or more | 2 (31,126) | 11 (3587) | 6 (4416) | 11 (2872) | 16 (1114) | 22 (641) | 15 (713) | 25 (235) | 2 (44,704) |
Follow-up information | |||||||||
 Mean (SD) follow-up (year) | 7.1 (3.2) | 6.3 (3.3) | 6.9 (3.2) | 5.4 (3.5) | 5.9 (3.3) | 4.7 (3.4) | 5.1 (3.4) | 4.5 (3.2) | 7.0 (3.3) |
 Person-years (1000s) | 13,178 | 211 | 494 | 137 | 42 | 14 | 24 | 4 | 14,105 |
 No. of deaths | 85,117 | 15,233 | 22,582 | 14,184 | 3961 | 2082 | 3121 | 714 | 146,994 |
 Mean (SD) age at death (years) | 78.7 (13.6) | 82.1 (9.4) | 79.3 (11.0) | 83.9 (9.4) | 79.7 (9.2) | 83.0 (8.5) | 81.0 (9.0) | 80.3 (8.1) | 79.3 (12.9) |
 Crude rate per 10,000 per year | 143.3 | 721.5 | 456.9 | 1037.9 | 927.2 | 1540.3 | 1279.9 | 1719.0 | 177.8 |