| No cardiometabolic disease at baseline | With cardiometabolic disease at baseline | ||||||
---|---|---|---|---|---|---|---|---|
Myocardial infarction | Diabetes | Stroke | Myocardial infarction and diabetes | Myocardial infarction and stroke | Stroke and diabetes | Myocardial infarction, stroke and diabetes | ||
No. of persons | 1,861,821 (52) | 33,581 (30) | 71,399 (47) | 25,136 (53) | 7206 (30) | 2901 (36) | 4753 (46) | 934 (33) |
No. of deaths | 85,117 | 15,233 | 22,582 | 14,184 | 3961 | 2082 | 3121 | 714 |
Hazard ratio (95% CI) | ||||||||
 Adjusted for sex, smoking, deprivation and comorbidities at baseline | 1.00 (0.99 to 1.01) | 1.21 (1.19 to 1.23) | 1.34 (1.32 to 1.35) | 1.47 (1.44 to 1.49) | 1.59 (1.55 to 1.63) | 1.46 (1.41 to 1.52) | 1.86 (1.81 to 1.90) | 1.72 (1.63 to 1.81) |
 Adjusted for sex, smoking, deprivation and number of comorbiditiesa at baseline | 1.00 (0.99 to 1.01) | 1.18 (1.16 to 1.19) | 1.32 (1.31 to 1.33) | 1.14 (1.13 to 1.16) | 1.47 (1.43 to 1.50) | 1.24 (1.19 to 1.28) | 1.37 (1.34 to 1.41) | 1.43 (1.36 to 1.50) |
 Adjusted for sex, smoking, deprivation and categories of comorbiditiesb at baseline | 1.00 (0.99 to 1.01) | 1.27 (1.26 to 1.29) | 1.40 (1.39 to 1.41) | 1.46 (1.44 to 1.48) | 1.73 (1.70 to 1.76) | 1.58 (1.54 to 1.63) | 1.91 (1.88 to 1.95) | 2.13 (2.05 to 2.20) |