Parameter | Median (95% range) | Source |
---|---|---|
Sensitivity of IGRA for infection, se | 61 (47–75) | [18] |
Specificity of IGRA for infection, sp | 96 (94–98) | [19] |
RR of infection if previously infected, p | 0.21 (0.14–0.30) | [17] |
Duration of preventive therapy, Dp | 3 months | Based on duration of 3HP |
Number of recent infection states, N | 20 | Gives total duration or recent infection of 5 years |
Duration of recent infection states, D | 3 months | |
Progression from remote infection, k | 1.5e−4 | See Additional file 1 |
Sensitivity for incident TB (over 15 months from testing) | ||
RISK11 (whole cohort) | 88.6 (43.5–98.7) | [14, 15] No incident TB cases amongst RISK11-negative participants not receiving IPT |
RISK11 (on ART and not receiving IPT) | 100 | |
RISK11 (ART naïve and not receiving IPT) | 100 | |
Optimum TPP | 90 | [9] |
Minimum TPP | 75 | |
Specificity for incident TB (over 15 months from testing) | ||
RISK11 (whole cohort) | 68.9 (65.3–72.3) | [14] |
RISK11 (on ART and not receiving IPT) | 70.2 (64.0–75.7) | |
RISK11 (ART naïve and not receiving IPT) | 45.9 (34.9–57.4) | |
Optimum TPP | 90 | [9] |
Minimum TPP | 75 |