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Table 3 Epidemiological estimates by HIV status, Kenya and Blantyre. TB incidence, case detection ratio, and smear-stratified symptom duration by HIV status for Kenya and Blantyre, Malawi

From: Durations of asymptomatic, symptomatic, and care-seeking phases of tuberculosis disease with a Bayesian analysis of prevalence survey and notification data

 

Kenya

Blantyre

HIV status

Non-HIV

PLHIV

Non-HIV

PLHIV

 

Background mortality

μ

μ + HIV-related mortality

μ

μ + HIV-related mortality

excess mortality for symptomatic TB

Smear−: 50%/10 years

Smear+: 70%/10 years

5% per month

Smear−: 50%/10 years

Smear+: 70%/10 years

5% per month

All TB regardless of symptomatic or not

 Time asymptomatic, month

10.35 (8.41–12.84)

3.81 (2.34–5.51)

3.22 (1.99–4.75)

8.79 (5.14–13.18)

1.32 (0.31–3.04)

1.15 (0.25–2.64)

 Time bacteriologically positive, month

20.90 (18.01–24.46)

7.79 (5.78– 9.99)

6.49 (4.94–8.11)

16.27 (11.59–21.53)

3.76 (1.81–6.07)

3.26 (1.76–5.03)

 Case-detection ratio

69% (59–81%)

84% (77–91%)

71% (63–80%)

76% (64–88%)

94% (88–98%)

84% (74–93%)

 Incidence rate in 2019, per 100,000

263 (221–306)

2025 (1873–2205)

2403 (2142–2715)

158 (132–192)

1742 (1618–1879)

1949 (1745–2217)

All symptomatic TB

 Time bacteriologically positive, month

10.56 (8.86–12.48)

3.99 (2.52–5.56)

3.27 (2.16–4.40)

7.47 (4.53–11.05)

2.44 (1.00–4.25)

2.11 (0.95–3.49)

 Case-detection ratio

83% (75–91%)

90% (85–95%)

76% (67–84%)

88% (79–95%)

95% (90–98%)

85% (75–94%)

 Incidence rate in 2019, per 100,000

218 (198–240)

1882 (1791–2003)

2260 (2025–2542)

136 (121–155)

1712 (1604–1831)

1921 (1721–2177)

  1. μ: background mortality based on the World Population Prospects, 2016 for Kenya and 2019 for Blantyre (Malawi)
  2. HIV-related mortality: AIDS-related deaths/PLHIV for aged 15 and above from the UNAIDS data
  3. 5% per month (0.61 per year): an extreme case for gold miner in pre-ART era [26]