Fig. 4
Effects of maternal SBP-increasing PGS on gestational week-specific fetal growth velocity. a Estimation of gestational week-specific estimated fetal weight (EFW) for individual fetus. Longitudinal ultrasound scan data at prenatal checkups are collected for individual fetus (colored circles) and the weekly values (continuous values) of EFW was estimated by smoothing splines interpolation. Data examples for four fetuses are shown (each fetus with a different color). b Gestational week-specific fetal growth velocity was calculated as the difference between two consecutive weekly EFW values. Fetuses are shown the same color as in a. c Distribution of normalized maternal SBP-increasing polygenic score (PGS) constituted of a set of SNPs exceeding a GWAS association p value of 1.0 × 10−4 and the stratification according to the tertiles. d Fetal growth velocity across maternal PGS tertiles. Each subject (n = 93) is shown in the box-and-whisker plots, with the boxes indicating the median and interquartile range and the whiskers denoting the range. Regression coefficient (Est.), standing for the change per strata increase, and p value are shown when p value is below the Bonferroni-corrected threshold for 8 tests (p = 6.3 × 10−3)