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Fig. 4 | BMC Medicine

Fig. 4

From: Polygenic risk score across distinct colorectal cancer screening outcomes: from premalignant polyps to colorectal cancer

Fig. 4

A Distribution of the adjusted polygenic risk score among negative fecal immunochemical test (FIT) result in cases and controls. B Receiver operating characteristic curve for based on 133 SNPs used to measure the area under the curve in negative FIT cases compared to negative FIT controls. C Positive and negative predicted values for the number of CRC risk alleles in negative FIT. The overall negative predictive value is 0.84. D Distribution of the polygenic risk score among positive FIT in cases and controls. E Receiver operating characteristic curve based on 133 SNPs used to measure the area under the curve in positive FIT cases compared to positive FIT controls F Positive and negative predicted values for the number of CRC risk alleles in positive FIT. The overall positive predictive value is 0.47

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