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Table 1 Characteristics of the overall study population stratified by categories following the classification by Castells et al.

From: Polygenic risk score across distinct colorectal cancer screening outcomes: from premalignant polyps to colorectal cancer

   Study Sex Family history Age (year) PRS Weighted PRS
  n (%) CRCGEN
n (%)
COLSCREEN
n (%)
Female
n (%)
Yesa
n (%)
Min Mean (SD) Max Min Mean (SD) Max Min Mean (SD) Max
Population control 1008 (28) 864 (48) 144 (8) 467 (30) 63 (20) 19 64.2 (12.0) 92 111 131.7 (7.2) 156 5.7 7.3 (0.4) 8.9
Screening control 670 (19) 670 (37) 406 (26) 48 (15) 49 59.5 (6.0) 70 111 131.5 (7.1) 149 6.0 7.2 (0.4) 8.7
LRL 286 (8) 286 (16) 125 (8) 24 (8) 49 60.3 (5.7) 71 110 131.8 (7.4) 151 6.0 7.3 (0.5) 8.4
IRL 352 (10) 352 (19) 126 ()8 20 (6) 49 59.8 (5.4) 70 111 132.6 (7.0) 151 6.0 7.4 (0.5) 8.7
HRL 226 (6) 226 (12) 65 (4) 15 (5) 50 60.6 (5.9) 70 114 133.7 (7.4) 150 6.2 7.4 (0.5) 8.5
Screening CRC 70 (2) 70 (4) 22 (1) 50 61.1 (5.9) 69 119 133.9 (6.4) 150 6.5 7.3 (0.4) 8.3
Clinically diagnosed CRC 1007 (28) 937 (52) 70 (4) 353 (23) 146 (46) 23 67.3 (11.0) 91 110 134.5 (7.0) 156 6.1 7.4 (0.4) 8.9
Total 3619 1801 (50) 1818 (50) 1564 (43) 316 (9) 19 63.1 (9.9) 92 110 132.7 (7.2) 156 5.7 7.3 (0.5) 8.9
  1. CRC colorectal cancer; CRCGEN Colorectal Cancer Genetics & Genomics study; COLSCREEN The Colorectal Cancer Screening Study; HRL high-risk lesion; IRL intermediate risk lesion; LRL low risk lesion; PRS adjusted polygenic risk score.
  2. aPercentages may differ due to missing values (n = 84)