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Table 1 Characteristics of the overall study population stratified by categories following the classification by Castells et al.

From: Polygenic risk score across distinct colorectal cancer screening outcomes: from premalignant polyps to colorectal cancer

  

Study

Sex

Family history

Age (year)

PRS

Weighted PRS

 

n (%)

CRCGEN

n (%)

COLSCREEN

n (%)

Female

n (%)

Yesa

n (%)

Min

Mean (SD)

Max

Min

Mean (SD)

Max

Min

Mean (SD)

Max

Population control

1008 (28)

864 (48)

144 (8)

467 (30)

63 (20)

19

64.2 (12.0)

92

111

131.7 (7.2)

156

5.7

7.3 (0.4)

8.9

Screening control

670 (19)

670 (37)

406 (26)

48 (15)

49

59.5 (6.0)

70

111

131.5 (7.1)

149

6.0

7.2 (0.4)

8.7

LRL

286 (8)

286 (16)

125 (8)

24 (8)

49

60.3 (5.7)

71

110

131.8 (7.4)

151

6.0

7.3 (0.5)

8.4

IRL

352 (10)

352 (19)

126 ()8

20 (6)

49

59.8 (5.4)

70

111

132.6 (7.0)

151

6.0

7.4 (0.5)

8.7

HRL

226 (6)

226 (12)

65 (4)

15 (5)

50

60.6 (5.9)

70

114

133.7 (7.4)

150

6.2

7.4 (0.5)

8.5

Screening CRC

70 (2)

70 (4)

22 (1)

50

61.1 (5.9)

69

119

133.9 (6.4)

150

6.5

7.3 (0.4)

8.3

Clinically diagnosed CRC

1007 (28)

937 (52)

70 (4)

353 (23)

146 (46)

23

67.3 (11.0)

91

110

134.5 (7.0)

156

6.1

7.4 (0.4)

8.9

Total

3619

1801 (50)

1818 (50)

1564 (43)

316 (9)

19

63.1 (9.9)

92

110

132.7 (7.2)

156

5.7

7.3 (0.5)

8.9

  1. CRC colorectal cancer; CRCGEN Colorectal Cancer Genetics & Genomics study; COLSCREEN The Colorectal Cancer Screening Study; HRL high-risk lesion; IRL intermediate risk lesion; LRL low risk lesion; PRS adjusted polygenic risk score.
  2. aPercentages may differ due to missing values (n = 84)