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Table 2 Characteristics of the CRC screening participants stratified by categories following the classification by Castells et al.

From: Polygenic risk score across distinct colorectal cancer screening outcomes: from premalignant polyps to colorectal cancer

   Study Sex Family history Age (year) FIT PRS Weighted PRS
  n (%) CRCGEN
n (%)
COLSCREEN
n (%)
Yes
n (%)
Yesa
n (%)
Min Mean (SD) Max Negative FITb
n (%)
Positive FITc
n (%)
Min Mean (SD) Max Min Mean (SD) Max
Screening control 670 (42) 670 (42) 406 (25) 48 (45) 49 59.5 (6.0) 70 226 (62) 444 (36) 111 131.5 (7.1) 149 6.0 7.2 (0.4) 8.7
LRL 286 (18) 286 (18) 125 (8) 24 (22) 49 60.3 (5.7) 71 78 (22) 208 (17) 110 131.8 (7.4) 151 6.0 7.3 (0.5) 8.4
IRL 352 (22 352 (22 126 (8) 20 (19) 49 59.8 (5.4) 70 43 (12) 309 (25) 111 132.6 (7.0) 151 6.0 7.4 (0.5) 8.7
HRL 226 (14) 226 (14) 65 (4) 15 (14) 50 60.6 (5.9) 70 14 (3.9) 212 (17) 114 133.7 (7.4) 150 6.2 7.4 (0.5) 8.5
Screening CRC 70 (4) 70 (4) 22 (1) 50 61.1 (5.9) 69 1 (0.1) 69 (6) 119 133.9 (6.4) 150 6.5 7.3 (0.4) 8.3
Total 1604 1604 744 (46) 107 (7) 49 59.9 (5.8) 71 362 (23) 1242 (77) 110 132.2 (7.2) 151 6.0 7.3 (0.5) 8.7
  1. CRC colorectal cancer; CRCGEN Colorectal Cancer Genetics & Genomics study; COLSCREEN The Colorectal Cancer Screening Study; FIT fecal immunochemical test; HRL high-risk lesion; IRL intermediate risk lesion; LRL low risk lesion; PRS adjusted polygenic risk score
  2. aPercentages may differ due to missing values (n = 38)
  3. bNegative FIT defined as < 20 μg Hb/g feces
  4. cPositive FIT defined as ≥ 20 μg Hb/g feces