Fig. 5

Relationship between postoperative CTC count and macroimmunity in peripheral blood. A Gene heatmap of 1729 significantly differentially expressed genes (p< 0.05, |log2-fold change|> 1.5) in 31 glioma patients. GliomaP: CTC-positive group, GliomaN: CTC-negative group. B Principal component analysis (PCA) of total genes for the CTC-positive group, CTC-negative group, and normal group. Red contour area: normal group, blue contour area: CTC-positive group, yellow contour area: CTC-negative group. C PCA of 455 immune-correlated genes with the CTC count for the CTC-positive group, CTC-negative group, and normal group. Red contour area: normal group, blue contour area: CTC-positive group, yellow contour area: CTC-negative group. D Gene heatmap of 171 immune-correlated genes (|Cor|> 0.4, p< 0.05) in 31 glioma patients. GliomaP: CTC-positive group, GliomaN: CTC-negative group. E The most significant Gene Ontology (GO) terms enriched in the genes of interest related to CTC counts. The color of the bar indicates the z-score. Upregulation (red, positive z-score), downregulation (blue, negative z score).