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Table 4 Characteristics of participants in Dataset 4

From: Prediction of P-tau/Aβ42 in the cerebrospinal fluid with blood microRNAs in Alzheimer’s disease

Characteristic Total Sample
(n = 503)
Controls
(n = 139)
AD
(n =155)
aMCI
(n =55)
VaD
(n =51)
PDD
(n =53)
bvFTD
(n =53)
DLB
(n =52)
Age, median (25th–75th percentile) 67 (63–72) 67 (65–73) 68 (63–73) 67 (64–70) 67 (63–70) 68 (64–73) 66 (62–70) 66 (62–70)
Education year, median (25th–75th percentile) 9 (8–11) 10 (9–11) 9 (8–10) 10 (8–12) 10 (8–11) 9 (8–10) 10.0 (9–11) 9.0 (7–11)
Women, No. (%) 255 (50.7) 71 (51.1) 79 (51.0) 28 (50.1) 24 (47.1) 26 (49.1) 28 (52.8) 27 (51.9)
ApoE ε4 positive (%) 133 (26.4) 25 (18.0) 64 (41.3)* 15 (27.3) 13 (25.5)* 10 (18.9) 11 (20.8) 10 (19.2)
MMSE score (SD) 23.4 (4.5) 29.1 (0.57) 20.8 (3.2)* 26.4 (0.6) 21.5 (2.9)* 21.0 (3.2)* 21.9 (3.0)* 21.8 (3.6)*
Aβ42, mean (SD), pg/ml 581.2 (184.7) 683.5 (135) 371.6 (80.7)* 507.3 (134.1)* 705 (108.5) 700.6 (127.6) 678.8 (141.5) 667.6 (142.4)
T-tau, mean (SD), pg/ml 449.2 (166.6) 340.1 (93.6) 595.6 (187.1) 474.3 (130.9) 395.5 (91.6) 359.2 (107.8) 448.6 (110.7) 422.6 (113.4)
P-tau, mean (SD), pg/ml 63.2 (31.5) 50.1 (19.5) 90.6 (37.7)* 65.6 (21.8)* 48.9 (17.7) 49 (13.5) 53 (22.6) 53.2 (25.1)
  1. The values of age, education year, and MMSE are shown as mean (SD)
  2. Abbreviations: AD, Alzheimer’s disease; VaD, vascular dementia; PDD, Parkinson disease dementia; bvFTD, behavioral variant frontotemporal dementia; DLB, dementia with Lewy body; ApoE ε4, apolipoprotein ε4; MMSE, Mini-Mental State Examination; SD, standard deviation
  3. *P < 0.05 compared to controls