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Table 1 Patient characteristics

From: Clinicopathologic analysis of microscopic tumor extension in glioma for external beam radiotherapy planning

Characteristic LGG HGG Total P**
n (%) n (%) n (%)
Patients 8 (21) 30 (79) 38 (100)  
Slides* 162 (20) 652 (80) 814 (100)  
Age (years)   0.056
 Mean (SD) 42 (7.52) 50.23 (11.07) 48.5 (10.87)  
 Median (IQR) 41 (38–48.75) 54 (46.75–56.25) 50.5 (44.5–55)  
Gender   0.709
 Male 5 (63) 16 (53) 21 (55)  
 Female 3 (38) 14 (47) 17 (45)  
Tumor grade   < 0.001
 Grade II 8 (100) 0 (0) 8 (21)  
 Grade III 0 (0) 17 (57) 17 (45)  
 Grade IV 0 (0) 13 (43) 13 (34)  
Histologic tumor size (cm)   0.126
 Mean (SD) 2.94 (1.03) 3.72 (1.31) 3.56 (1.29)  
 Median (IQR) 2.76 (2.27–3.65) 3.96 (2.69–4.72) 3.65 (2.43–4.67)  
Histologic PTBE size (cm)   < 0.001
 Mean (SD) 1.00 (0.45) 2.22 (0.54) 1.96 (0.72)  
 Median (IQR) 1.15 (0.48–1.35) 2.12 (1.84–2.86) 2.00 (1.45–2.43)  
Contrast enhancement   < 0.001
 Yes 0 (0) 30 (100) 30 (79)  
 No 8 (100) 0 (0) 8 (21)  
Lesion site   0.860
 Frontal lobe 5 (63) 16 (53) 21 (55)  
 Temporal lobe 2 (25) 11 (37) 13 (34)  
 Occipital lobe 1 (13) 3 (10) 4 (11)  
MGMT methylation status   0.426
 Unmethylated 5 (63) 12 (40) 17 (45)  
 Methylated 3 (38) 18 (60) 21 (55)  
IDH mutation   0.698
 Mutated 4 (50) 12 (40) 16 (42)  
 Wild type 4 (50) 18 (60) 22 (58)  
1p/19q co-deletion   0.689
 Co-deleted 2 (25) 11 (37) 13 (34)  
 Non-co-deleted 6 (75) 19 (63) 25 (66)  
  1. Abbreviation: LGG low-grade glioma; HGG high-grade glioma; SD standard deviation; IQR interquartile range; PTBE peritumoral brain edema; MGMT O6-methylguanine-DNA-methyltransferase; IDH isocitrate dehydrogenase; 1p/19q co-deletion, the co-deletion of chromosome arms 1p and 19q
  2. *Number of slides presenting this criterion
  3. **P value according to the Student’s t-test or Fisher's exact test