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Table 6 Variables associated with ME distance in univariate and multivariate linear regression model

From: Clinicopathologic analysis of microscopic tumor extension in glioma for external beam radiotherapy planning

Variables

Univariate analysis

Multivariate analysis

β (95% CI)

P value

β (95% CI)

P value

VIF

Age (years)

0.004 (−0.014 to 0.021)

0.652

   

Gender

 Male/female

0.150 (−0.225 to 0.526)

0.421

   

Tumor grade

  

 LGG/HGG

0.884 (0.532–1.236)

< 0.001

0.822 (0.584–1.060)

< 0.001

1.078

Histologic tumor size (cm)

0.092 (−0.053 to 0.237)

0.208

   

Histologic PTBE size (cm)

0.199 (−0.056 to 0.454)

0.122

   

Tumor location

 Frontal lobe

Ref.

Ref.

   

 Temporal lobe

−0.133 (−0.528 to 0.261)

0.497

   

 Occipital lobe

−0.388 (−0.987 to 0.212)

0.198

   

Molecular markers

 MGMT methylation status

  

  Unmethylated/Methylated

0.456 (0.110–0.802)

0.011

0.259 (0.066–0.453)

0.010

1.060

 IDH mutation

  

  Mutated/wild type

0.617 (0.298–0.936)

< 0.001

0.391 (0.168–0.613)

0.001

1.382

 1p/19q co-deletion

  

  Co-deleted/non-co-deleted

0.472 (0.109–0.836)

0.012

0.300 (0.066–0.534)

0.013

1.412

  1. Abbreviation: ME microscopic extension; β regression coefficient; CI confidence interval; VIF variance inflation factor; LGG low-grade glioma; HGG high-grade glioma; PTBE peritumoral brain edema; MGMT O6-methylguanine-DNA-methyltransferase; IDH isocitrate dehydrogenase; 1p/19q co-deletion the co-deletion of chromosome arms 1p and 19q
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BMC Medicine

ISSN: 1741-7015

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