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Table 6 Variables associated with ME distance in univariate and multivariate linear regression model

From: Clinicopathologic analysis of microscopic tumor extension in glioma for external beam radiotherapy planning

Variables Univariate analysis Multivariate analysis
β (95% CI) P value β (95% CI) P value VIF
Age (years) 0.004 (−0.014 to 0.021) 0.652    
Gender
 Male/female 0.150 (−0.225 to 0.526) 0.421    
Tumor grade   
 LGG/HGG 0.884 (0.532–1.236) < 0.001 0.822 (0.584–1.060) < 0.001 1.078
Histologic tumor size (cm) 0.092 (−0.053 to 0.237) 0.208    
Histologic PTBE size (cm) 0.199 (−0.056 to 0.454) 0.122    
Tumor location
 Frontal lobe Ref. Ref.    
 Temporal lobe −0.133 (−0.528 to 0.261) 0.497    
 Occipital lobe −0.388 (−0.987 to 0.212) 0.198    
Molecular markers
 MGMT methylation status   
  Unmethylated/Methylated 0.456 (0.110–0.802) 0.011 0.259 (0.066–0.453) 0.010 1.060
 IDH mutation   
  Mutated/wild type 0.617 (0.298–0.936) < 0.001 0.391 (0.168–0.613) 0.001 1.382
 1p/19q co-deletion   
  Co-deleted/non-co-deleted 0.472 (0.109–0.836) 0.012 0.300 (0.066–0.534) 0.013 1.412
  1. Abbreviation: ME microscopic extension; β regression coefficient; CI confidence interval; VIF variance inflation factor; LGG low-grade glioma; HGG high-grade glioma; PTBE peritumoral brain edema; MGMT O6-methylguanine-DNA-methyltransferase; IDH isocitrate dehydrogenase; 1p/19q co-deletion the co-deletion of chromosome arms 1p and 19q