Table 3 Frequency of individual symptoms (n and % of participants who reported it at least once during study participation more than 2 weeks after baseline and prior to vaccination) in relation to baseline serology (total of 4812 participants). Symptoms are sorted by increasing risk ratio (RR)
Symptom | N (%) of HCWs reporting a symptom | RR (95% CI) | P value prop.test* | P value adjusted** | |
|---|---|---|---|---|---|
Seronegatives | Seropositives | ||||
N = 4668 | N = 144 | ||||
Olfaction/taste impaired | 588 (12.6%) | 6 (4.2%) | 0.33 (0.15–0.73) | 0.004 | 0.001 |
Fever > 38 °C | 348 (7.5%) | 6 (4.2%) | 0.56 (0.25–1.23) | 0.185 | 0.101 |
Chills | 1040 (22.3%) | 19 (13.2%) | 0.59 (0.39–0.90) | 0.013 | 0.005 |
Limb/muscle pain | 1335 (28.6%) | 28 (19.4%) | 0.68 (0.49–0.95) | 0.021 | 0.01 |
Coryza/nasal congestion | 2094 (44.9%) | 55 (38.2%) | 0.85 (0.69–1.05) | 0.134 | 0.083 |
Headache | 2058 (44.1%) | 55 (38.2%) | 0.87 (0.70–1.07) | 0.187 | 0.126 |
Anorexia/nausea | 935 (20%) | 25 (17.4%) | 0.87 (0.60–1.24) | 0.494 | 0.393 |
Sore throat | 1940 (41.6%) | 53 (36.8%) | 0.89 (0.71–1.10) | 0.292 | 0.207 |
Weakness | 2196 (47%) | 60 (41.7%) | 0.89 (0.73–1.08) | 0.235 | 0.162 |
Cough | 1478 (31.7%) | 41 (28.5%) | 0.90 (0.69–1.17) | 0.471 | 0.37 |
Dyspnea | 326 (7%) | 10 (6.9%) | 0.99 (0.54–1.82) | 1 | 0.962 |
Eye irritation | 641 (13.7%) | 21 (14.6%) | 1.06 (0.71–1.59) | 0.866 | 0.805 |
Fevery feeling | 295 (6.3%) | 10 (6.9%) | 1.10 (0.60–2.02) | 0.897 | 0.789 |
Dizziness | 801 (17.2%) | 28 (19.4%) | 1.13 (0.81–1.59) | 0.546 | 0.509 |
Diarrhea | 751 (16.1%) | 29 (20.1%) | 1.25 (0.90–1.74) | 0.236 | 0.222 |