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Table 2 Comparison of 5-year prognostic performance by the five models for different clinicopathological subgroups

From: Computer-assisted quantification of tumor-associated collagen signatures to improve the prognosis prediction of breast cancer

Variable

CLI

TCMF-score

TACS-score

TCMF+TACS

CLI+TCMF+TACS

 

HR

AUC

HR

AUC

HR

AUC

HR

AUC

HR

AUC

Age

 ≤50

3.320

0.729

4.112

0.778

5.869

0.823

7.201

0.854

9.069

0.889

 >50

3.282

0.739

3.323

0.788

5.999

0.833

7.653

0.872

9.243

0.902

Molecular subtype

 Luminal A

1.749

0.601

5.738

0.827

3.594

0.761

4.060

0.816

4.581

0.821

 Luminal B

2.789

0.720

4.647

0.835

6.042

0.838

7.490

0.889

9.296

0.901

 HER2-enriched

4.386

0.769

2.541

0.719

9.151

0.862

10.000

0.868

11.716

0.917

 Triple negative

3.431

0.735

2.404

0.696

6.285

0.863

10.009

0.859

9.107

0.893

Tumor size

 ≤2cm

2.824

0.683

3.959

0.782

5.976

0.818

7.001

0.855

6.899

0.872

 2–5cm

3.150

0.725

3.987

0.789

6.209

0.839

8.264

0.871

10.631

0.897

 >5cm

23.874

0.859

2.314

0.818

3.964

0.844

4.425

0.890

8.767

0.942

Nodal status

 0

2.874

0.628

3.343

0.751

5.443

0.820

6.808

0.856

8.250

0.880

 1–3

1.681

0.593

4.330

0.799

3.871

0.758

5.216

0.813

6.086

0.829

 ≥4

4.332

0.728

2.826

0.788

6.337

0.865

7.433

0.881

10.753

0.910

Clinical stage

 I

4.024

0.615

3.299

0.741

4.071

0.797

5.042

0.833

6.546

0.865

 II

1.881

0.609

4.143

0.790

5.256

0.798

7.012

0.844

8.048

0.862

 III

3.773

0.724

2.722

0.775

6.102

0.863

7.125

0.876

9.500

0.904

Histological grade

 G1

3.214

0.703

5.206

0.811

4.889

0.769

8.407

0.849

10.520

0.876

 G2

3.422

0.725

4.122

0.794

6.095

0.840

7.098

0.866

8.016

0.893

 G3

2.810

0.733

2.639

0.749

6.528

0.845

8.775

0.874

10.677

0.898

ER status

 Positive

2.989

0.721

5.174

0.833

5.187

0.811

6.408

0.866

8.350

0.889

 Negative

3.820

0.752

2.495

0.709

7.722

0.864

10.056

0.868

10.508

0.906

PR status

 Positive

3.116

0.721

6.026

0.844

5.178

0.807

7.354

0.865

8.698

0.891

 Negative

3.416

0.744

2.473

0.719

7.219

0.859

8.012

0.867

9.562

0.899

HER2 status

 Negative

3.435

0.736

4.083

0.790

5.158

0.818

7.250

0.857

8.952

0.890

 Positive

2.993

0.726

3.209

0.776

8.230

0.852

8.506

0.881

9.530

0.903

  1. Note: ER, estrogen receptor; PR, progesterone receptor