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Table 2 Comparison of 5-year prognostic performance by the five models for different clinicopathological subgroups

From: Computer-assisted quantification of tumor-associated collagen signatures to improve the prognosis prediction of breast cancer

Variable CLI TCMF-score TACS-score TCMF+TACS CLI+TCMF+TACS
  HR AUC HR AUC HR AUC HR AUC HR AUC
Age
 ≤50 3.320 0.729 4.112 0.778 5.869 0.823 7.201 0.854 9.069 0.889
 >50 3.282 0.739 3.323 0.788 5.999 0.833 7.653 0.872 9.243 0.902
Molecular subtype
 Luminal A 1.749 0.601 5.738 0.827 3.594 0.761 4.060 0.816 4.581 0.821
 Luminal B 2.789 0.720 4.647 0.835 6.042 0.838 7.490 0.889 9.296 0.901
 HER2-enriched 4.386 0.769 2.541 0.719 9.151 0.862 10.000 0.868 11.716 0.917
 Triple negative 3.431 0.735 2.404 0.696 6.285 0.863 10.009 0.859 9.107 0.893
Tumor size
 ≤2cm 2.824 0.683 3.959 0.782 5.976 0.818 7.001 0.855 6.899 0.872
 2–5cm 3.150 0.725 3.987 0.789 6.209 0.839 8.264 0.871 10.631 0.897
 >5cm 23.874 0.859 2.314 0.818 3.964 0.844 4.425 0.890 8.767 0.942
Nodal status
 0 2.874 0.628 3.343 0.751 5.443 0.820 6.808 0.856 8.250 0.880
 1–3 1.681 0.593 4.330 0.799 3.871 0.758 5.216 0.813 6.086 0.829
 ≥4 4.332 0.728 2.826 0.788 6.337 0.865 7.433 0.881 10.753 0.910
Clinical stage
 I 4.024 0.615 3.299 0.741 4.071 0.797 5.042 0.833 6.546 0.865
 II 1.881 0.609 4.143 0.790 5.256 0.798 7.012 0.844 8.048 0.862
 III 3.773 0.724 2.722 0.775 6.102 0.863 7.125 0.876 9.500 0.904
Histological grade
 G1 3.214 0.703 5.206 0.811 4.889 0.769 8.407 0.849 10.520 0.876
 G2 3.422 0.725 4.122 0.794 6.095 0.840 7.098 0.866 8.016 0.893
 G3 2.810 0.733 2.639 0.749 6.528 0.845 8.775 0.874 10.677 0.898
ER status
 Positive 2.989 0.721 5.174 0.833 5.187 0.811 6.408 0.866 8.350 0.889
 Negative 3.820 0.752 2.495 0.709 7.722 0.864 10.056 0.868 10.508 0.906
PR status
 Positive 3.116 0.721 6.026 0.844 5.178 0.807 7.354 0.865 8.698 0.891
 Negative 3.416 0.744 2.473 0.719 7.219 0.859 8.012 0.867 9.562 0.899
HER2 status
 Negative 3.435 0.736 4.083 0.790 5.158 0.818 7.250 0.857 8.952 0.890
 Positive 2.993 0.726 3.209 0.776 8.230 0.852 8.506 0.881 9.530 0.903
  1. Note: ER, estrogen receptor; PR, progesterone receptor