Fig. 7
The m6A score predicts anti-PD-1 immunotherapy response in SCLC. A Representative immunohistochemical images of CD8+ T cell infiltration in SCLCs from the low- (case 1) and high-score (case 2) groups, respectively. The black arrows indicate the CD8 markers. B Pearson correlation analysis the CD8+ T cell density (log2 transformed) and the m6A score. C The density of CD8+ T cells (log2 transformed) in the low- and high-score groups. D A waterfall plot of m6A score distribution in patients with anti-PD-1 immunotherapy. Blue, pink, and red represent partial response (PR), stable disease (SD), and progressive disease (PD), respectively. E Differences of m6A scores in responders (PR) and non-responders (SD and PD). F ROC curves for the performance of the m6A score in predicting non-responders of immunotherapy in SCLC