Table 1 Causal estimates of atrial fibrillation on brain gray or white matter volume in the UK Biobank participants by summary-level Mendelian randomization
Genetically predicted exposure | Outcome phenotype | MR-Egger intercept P value | Cochran’s Q statistic P value for heterogeneity | MR method | Beta | Standard error | P value |
|---|---|---|---|---|---|---|---|
Atrial fibrillation (16 SNPs) | Gray matter volume (normalized) | 0.984 | 0.547 | IVW | −0.040 | 0.017 | 0.017 |
MR-Egger (bootstrap) | −0.044 | 0.040 | 0.147 | ||||
Weighted median | −0.047 | 0.023 | 0.044 | ||||
MR-RAPS | −0.043 | 0.017 | 0.014 | ||||
MR-PRESSO | NA | NA | NA | ||||
Gray matter volume (unnormalized) | 0.817 | 0.499 | IVW | −0.041 | 0.017 | 0.015 | |
MR-Egger (bootstrap) | −0.052 | 0.040 | 0.089 | ||||
Weighted median | −0.050 | 0.023 | 0.033 | ||||
MR-RAPS | −0.044 | 0.017 | 0.013 | ||||
MR-PRESSO | NA | NA | NA | ||||
White matter volume (normalized) | 0.549 | 0.041 | IVW | −0.016 | 0.022 | 0.465 | |
MR-Egger (bootstrap) | −0.038 | 0.042 | 0.186 | ||||
Weighted median | −0.027 | 0.023 | 0.242 | ||||
MR-RAPS | −0.015 | 0.022 | 0.483 | ||||
MR-PRESSO | NA | NA | NA | ||||
White matter volume (unnormalized) | 0.553 | 0.053 | IVW | −0.016 | 0.022 | 0.464 | |
MR-Egger (bootstrap) | −0.038 | 0.041 | 0.181 | ||||
Weighted median | −0.028 | 0.024 | 0.241 | ||||
MR-RAPS | −0.016 | 0.022 | 0.470 | ||||
MR-PRESSO | NA | NA | NA |