Skip to main content

Table 1 Causal estimates of atrial fibrillation on brain gray or white matter volume in the UK Biobank participants by summary-level Mendelian randomization

From: Causal effects of atrial fibrillation on brain white and gray matter volume: a Mendelian randomization study

Genetically predicted exposure Outcome phenotype MR-Egger intercept P value Cochran’s Q statistic P value for heterogeneity MR method Beta Standard error P value
Atrial fibrillation (16 SNPs) Gray matter volume (normalized) 0.984 0.547 IVW −0.040 0.017 0.017
MR-Egger (bootstrap) −0.044 0.040 0.147
Weighted median −0.047 0.023 0.044
MR-RAPS −0.043 0.017 0.014
MR-PRESSO NA NA NA
Gray matter volume (unnormalized) 0.817 0.499 IVW −0.041 0.017 0.015
MR-Egger (bootstrap) −0.052 0.040 0.089
Weighted median −0.050 0.023 0.033
MR-RAPS −0.044 0.017 0.013
MR-PRESSO NA NA NA
White matter volume (normalized) 0.549 0.041 IVW −0.016 0.022 0.465
MR-Egger (bootstrap) −0.038 0.042 0.186
Weighted median −0.027 0.023 0.242
MR-RAPS −0.015 0.022 0.483
MR-PRESSO NA NA NA
White matter volume (unnormalized) 0.553 0.053 IVW −0.016 0.022 0.464
MR-Egger (bootstrap) −0.038 0.041 0.181
Weighted median −0.028 0.024 0.241
MR-RAPS −0.016 0.022 0.470
MR-PRESSO NA NA NA
  1. MR Mendelian randomization, IVW inverse variance–weighted, RAPS robust adjusted profile score, PRESSO pleiotropy residual sum and outlier, SNP single-nucleotide polymorphism
  2. MR-PRESSO analysis was performed, but the MR-PRESSO global test for heterogeneity did not identify correctable effects of outliers
  3. The units of the causal estimates were log odds ratio for the cause (atrial fibrillation) and standard deviation for the effect (brain volume)