Fig. 3
From: IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis
Identified loci associated with RNA:DNA ratio. A Manhattan plot of QTL mapping analysis for the RNA:DNA ratio. No genome-wide significant locus was identified at the threshold of P < 5 × 10−8; however, we identified two suggestive associations with the RNA:DNA ratio at the threshold of P < 5 × 10−7. B Box plot for each genotype of rs2613996 from QTL mapping analysis for the RNA:DNA ratio. The top SNP, rs2613996 is suggestively associated with the trait (P = 2.19 × 10−7). This SNP is also the top SNP of the locus identified as genome-wide significant association with CA HIV-1 DNA. C LocusZoom plot of the independent SNP of QTL mapping analysis for CA HIV-1 DNA on chromosome 11 (rs2613996)