Fig. 4

Correlation between IHC staining of MCL-1 and BCL-xL and OS in NOXA^low TH and TC and re-expression of NOXA in 1889c. A Kaplan-Meier analysis of NOXA^low/MCL-1^low/BCL-xL^low (n = 17), NOXA^low/MCL-1^high/BCL-xL^low (n = 10), and NOXA^low/MCL-1^high/BCL-xL^high (n = 8) resolve a significant better OS for patients with low NOXA signal depending on MCL-1 and BCL-xL signals (p = 0.0029*). B Western blot analysis of 1889c cells transfected with control or NOXA plasmid. C Cell viability assay of 1889c after induced expression of NOXA. D Cell viability assay of NOXA transfected 1889c cells after a 24-h single treatment with AZD5991 (0.5μM) or combined treatment with A-1155463 (0.05μM) or ABT-263 (0.5μM)