Fig. 2

5mC clusters accurately predicted classical molecular subtypes and therapeutic opportunities in the TCGA-BLCA cohort. A, B The correlations between 5mC clusters, 5mC score, and seven classical molecular subtype classifications. C ROC curves showed the accuracy of the 5mC score in predicting classical molecular subtypes. D, E The overall mutation rates of neoadjuvant chemotherapy-related genes in the 5mC score groups. F The correlations between the 5mC score and the enrichment scores of several therapeutic signatures, such as targeted therapy and radiotherapy. G The correlations between the 5mC score and the BLCA-related drug-target genes were screened from the DrugBank database