Fig. 5

Validating the roles of the 5mC score in the Xiangya cohort. A The correlations between the 5mC score and seven classical molecular subtype classifications. (B) ROC curves showed the accuracy of the 5mC score in predicting classical molecular subtypes. C The correlations between the 5mC score and the cancer immunity cycles. D The correlations between the 5mC score and the enrichment scores of positive ICB response-related signatures. E The correlations between the 5mC score and 22 immune checkpoints. F The correlation between the 5mC score and the infiltration levels of five anticancer TIICs (CD8+ T cells, NK cells, macrophages, Th1 cells, and dendritic cells), which were calculated using seven independent algorithms. G The correlations between the 5mC score and TIS. H The differences in the enrichment scores of several therapeutic signatures, such as targeted therapy and radiotherapy, between the 5mC score groups