From: Different hypertension thresholds and cognitive decline: a pooled analysis of three ageing cohorts
BP Group | HRS (n = 2810) | ELSA (n = 2338) | CHARLS (n = 2533) | Pooled analysis (n = 7681) | ||||||
---|---|---|---|---|---|---|---|---|---|---|
β (95% Cl)* | P value | β (95% Cl)* | P value | β (95% Cl)* | P value | Pooled β (95% Cl)* | P value | I2 (%) | P value | |
Global | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Normal | −0.018 (− 0.032 to − 0.005) | 0.008 | 0.005 (−0.012 to 0.023) | 0.551 | −0.003 (− 0.020 to 0.013) | 0.687 | − 0.006 (− 0.020 to 0.008) | 0.377 | 58.3 | 0.091 |
 Borderline | Reference | / | Reference | / | Reference | / | Reference | / | / | / |
 High | −0.015 (−0.024 to − 0.005) | 0.002 | −0.003 (− 0.013 to 0.008) | 0.626 | −0.016 (− 0.030 to − 0.002) | 0.025 | −0.011 (− 0.020 to − 0.002) | 0.013 | 43.7 | 0.169 |
Memory | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Normal | −0.008 (−0.018 to 0.002) | 0.097 | 0.010 (− 0.002 to 0.021) | 0.099 | −0.013 (− 0.034 to 0.009) | 0.257 | −0.003 (− 0.016 to 0.011) | 0.715 | 69.2 | 0.039 |
 Borderline | Reference | / | Reference | / | Reference | / | Reference | / | / | / |
 High | −0.006 (− 0.013 to 0.001) | 0.076 | −0.001 (− 0.008 to 0.006) | 0.852 | −0.018 (− 0.036 to 0.001) | 0.060 | −0.005 (− 0.012 to 0.002) | 0.138 | 40.7 | 0.185 |
Executive function | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Normal | −0.008 (− 0.018 to 0.002) | 0.107 | 0.007 (−0.005 to 0.019) | 0.276 | −0.001 (− 0.017 to 0.015) | 0.902 | −0.001 (− 0.011 to 0.008) | 0.777 | 42.2 | 0.177 |
 Borderline | Reference | / | Reference | / | Reference | / | Reference | / | / | / |
 High | −0.003 (− 0.010 to 0.004) | 0.404 | −0.006 (− 0.014 to 0.001) | 0.108 | −0.012 (− 0.025 to 0.002) | 0.101 | −0.005 (− 0.010 to 0.000) | 0.031 | 0.0 | 0.513 |
Orientation | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Normal | −0.021 (− 0.039 to − 0.003) | 0.025 | −0.004 (− 0.025 to 0.016) | 0.677 | 0.011 (−0.006 to 0.029) | 0.210 | −0.005 (− 0.024 to 0.015) | 0.640 | 67.6 | 0.046 |
 Borderline | Reference | / | Reference | / | Reference | / | Reference | / | / | / |
 High | −0.019 (− 0.032 to − 0.007) | 0.003 | 0.004 (−0.009 to 0.016) | 0.573 | 0.002 (−0.013 to 0.017) | 0.749 | −0.005 (− 0.020 to 0.011) | 0.550 | 73.6 | 0.023 |