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Fig. 4 | BMC Medicine

Fig. 4

From: A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens

Fig. 4

Expression pattern of EYA4 in the human cochlea. A EYA4 expression is observed in membranous labyrinth supporting cell nuclei: within the organ of Corti, the inner and outer sulcus, cells of Claudius, and spiral limbus interdental cells. Parvalbumin stains the inner and outer hair cells red. Nuclei were stained with DAPI. B Close-up of the organ of Corti reveals EYA4 expression in the outer hair cells as well as supporting cells: phalangeal cells, pillar cells, Deiters cells, Hensen cells, and Boettcher cells. Cells beneath the basilar membrane lack EYA4 expression. C EYA4 is expressed in the spiral ganglion cells. ICs = inderdental cells, IS = inner sulcus, OC = organ of Corti, Cl = cells of Claudius, IHC = inner hair cell, OHCs = outer hair cells, HCs = Hensen cells, Ph = phalangeal cells

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