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Table 2 Summary of human cochlear expression of proteins linked to hearing-related traits in the UK Biobank

From: A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens

 

Spiral ganglion

Hair cells

Scala media-facing epithelial cells

Protein

Type I neurons

Outer spiral bundles

Inner

Outer

Inner sulcus cells

Inter-dental cells

Border cells

Phalangeal cells

Pillar cells

Deiters cells

Hensen cells

Boettcher cells

Claudius cells

Outer sulcus cells

Stria vascularis

EYA4

+

+

+

+

+

+

+

+

+

+

+

+

+

(−)

LMX1A

+

+

(+)

+

(−)

(−)

(−)

(−)

PTK2/FAK

+

+

(−)

(−)

(−)

(−)

UBE3B

+

(−)

MMP2

+

+

(−)

(−)

(−)

(−)

(−)

(−)

(−)

(−)

(−)

SYNJ2

+

+

(−)

(−)

(−)

(−)

(−)

(−)

(−)

(−)

(−)

GRM5

+

(−)

(−)

(−)

(−)

(−)

(−)

(−)

(−)

(−)

(−)

(−)

(−)

(−)

(−)

TRIOBP

+

+

+

+

(−)

(−)

(−)

(−)

LMO7

(+)

(+)

+

+

(−)

(−)

(−)

(−)

(−)

(−)

(−)

(−)

NOX4

+

+

+

+

+

+

+

(+)

+

(−)

(−)

+

+

  1. “+” positive protein expression detected by immunohistochemical staining. “−” expression was not detected in this structure. (+) Weak staining in the immunohistochemical imaging suggests the presence of protein in the structure. (−) expression was not detected in this structure (data not presented in this paper)