No lithium n= 853,583 | Lithium use n=434 | |||
---|---|---|---|---|
n (%) | n (%) | Relative risk (95% confidence interval) | ||
Crude | Adjusted | |||
Primary outcomes | ||||
Preeclampsia | 24,008 (2.8) | 15 (3.5) | 1.29 (0.75, 2.02) | 1.01 (0.59, 1.73) |
Spontaneous preterm birth Missing n=723 | 25,268 (3.0) | 36 (8.7) | 2.80 (2.02, 3.88) | 2.64 (1.82, 3.82) |
Small for gestational age Missing n=1446 | 19,794 (2.3) | 13 (3.0) | 1.29 (0.70, 2.38) | 1.05 (0.54, 2.06) |
Large for gestational age Missing n=1446 | 29,619 (3.5) | 39 (9.0) | 2.59 (1.91, 3.51) | 2.64 (1.91, 3.66) |
Secondary outcomes | ||||
Macrosomia Missing n=1116 | 158,461 (18.6) | 93 (21.4) | 1.01 (0.25, 4.03) | 1.05 (0.25, 4.32) |
Hypoglycaemia | 20,877 (2.5) | 24 (5.5) | 2.26 (1.54, 3.33) | 1.46 (0.89, 2.40) |
Five-minute Apgar < 6 Missing n=5011 | 11,221 (1.3) | 11 (2.5) | 1.92 (1.02, 3.61) | 0.92 (0.38, 2.22) |
Malformations (all) | 29,240 (3.4) | 19 (4.4) | 1.28 (0.83, 1.98) | 1.41 (0.90, 2.23) |
Cardiac malformations | 6513 (0.8) | 9 (2.1) | 2.72 (1.43, 5.17) | 3.17 (1.64, 6.13) |
Perinatal death | 3567 (0.5) | 2 (0.5) | 1.58 (0.39, 6.27) | 1.08 (0.15, 7.67) |