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Table 2 Primary outcome compared to whole population

From: Maternal lithium use and the risk of adverse pregnancy and neonatal outcomes: a Swedish population-based cohort study

 

No lithium

n= 853,583

Lithium use

n=434

 

n (%)

n (%)

Relative risk (95% confidence interval)

Crude

Adjusted

Primary outcomes

 Preeclampsia

24,008 (2.8)

15 (3.5)

1.29 (0.75, 2.02)

1.01 (0.59, 1.73)

 Spontaneous preterm birth

Missing n=723

25,268 (3.0)

36 (8.7)

2.80 (2.02, 3.88)

2.64 (1.82, 3.82)

 Small for gestational age

Missing n=1446

19,794 (2.3)

13 (3.0)

1.29 (0.70, 2.38)

1.05 (0.54, 2.06)

 Large for gestational age

Missing n=1446

29,619 (3.5)

39 (9.0)

2.59 (1.91, 3.51)

2.64 (1.91, 3.66)

Secondary outcomes

 Macrosomia

Missing n=1116

158,461 (18.6)

93 (21.4)

1.01 (0.25, 4.03)

1.05 (0.25, 4.32)

 Hypoglycaemia

20,877 (2.5)

24 (5.5)

2.26 (1.54, 3.33)

1.46 (0.89, 2.40)

 Five-minute Apgar < 6 Missing n=5011

11,221 (1.3)

11 (2.5)

1.92 (1.02, 3.61)

0.92 (0.38, 2.22)

 Malformations (all)

29,240 (3.4)

19 (4.4)

1.28 (0.83, 1.98)

1.41 (0.90, 2.23)

 Cardiac malformations

6513 (0.8)

9 (2.1)

2.72 (1.43, 5.17)

3.17 (1.64, 6.13)

 Perinatal death

3567 (0.5)

2 (0.5)

1.58 (0.39, 6.27)

1.08 (0.15, 7.67)

  1. Adjusted analyses were retrieved via inverse probability weighting with maternal age, body mass index, smoking status, country of birth, education, parity, maternal psychiatric illness (schizophrenia, psychosis) and medical conditions, and the use of antipsychotics, neuroleptics and lamotrigine during pregnancy were included as covariates