Lithium prior n=871 | Lithium during n=434 | |||
---|---|---|---|---|
n (%) | n (%) | Relative risk (95% confidence interval) | ||
Crude | Adjusted | |||
Primary outcomes | ||||
Preeclampsia | 33 (3.8) | 15 (3.5) | 0.91 (0.50, 1.67) | 0.86 (0.44, 1.70) |
Spontaneous preterm birth | 37 (4.4) | 36 (8.7) | 1.95 (1.23, 3.09) | 2.08 (1.20, 3.59) |
Small for gestational age | 31 (3.6) | 13 (3.0) | 0.84 (0.42, 1.70) | 0.91 (0.42, 2.01) |
Large for gestational age | 37 (4.3) | 39 (9.0) | 2.12 (1.37, 3.28) | 1.86 (1.10, 3.13) |
Secondary outcomes | ||||
Macrosomia | 138 (15.8) | 93 (21.4) | 0.67 (0.14, 3.30) | 0.50 (0.09, 2.68) |
Hypoglycaemia | 23 (2.6) | 24 (5.5) | 2.09 (1.20, 3.66) | 2.72 (1.47, 5.04) |
Five-minute Apgar < 6 | 16 (1.9) | 11 (2.5) | 1.37 (0.62, 3.04) | 2.25 (0.89, 5.66) |
Malformations (all) | 25 (2.9) | 19 (4.4) | 1.52 (0.85, 2.73) | 1.47 (0.77, 2.80) |
Cardiac malformations | 7 (0.8) | 9 (2.1) | 2.58 (0.97, 6.86) | 2.99 (1.10, 8.10)_ |
Perinatal death | 3 (0.3) | 2 (0.5) | 2.68 (0.45, 15.90) | 2.26 (0.21, 24.54) |