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Fig. 3 | BMC Medicine

Fig. 3

From: P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss

Fig. 3

Changes of placental ryanodine receptor/C-Jun N-terminal kinase/Y-box protein 1 (RYR/JNK/YB-1) pathway and histone acetylation of ATP-binding cassette, sub-family B, member 1a/b (abcb1a/b) promoter region of prenatal caffeine exposure-induced intrauterine growth retardation rat model. A Relative mRNA expression levels of RYRs, n=10–12; B Relative protein expression of placental JNK, p-JNK, and E1A binding protein P300 (P300) was standardized by GAPDH, and relative protein expression of nucleus YB-1 was standardized by H3, n=3; C, D Histone 3 Lysine 9 (H3K9) and histone 3 Lysine 14 (H3K14) acetylation levels in the promoter region of abcb1a and abcb1b, n=3. Mean ± S.E.M. *P<0.05, **P<0.01 vs. control

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