| Full sample | One endpoint per review | Studies reported in multiple reviews excluded | |||
---|---|---|---|---|---|---|
 | Proportion | % | Proportion | % | Proportion | % |
Effect estimates of observational studies and RCTs in opposite directions | 30/74 | 40.5 | 11/29 | 37.9 | 26/65 | 40.0 |
RCT effect estimate outside the observational study 95% CI | 35/74 | 47.3 | 17/29 | 58.6 | 29/65 | 44.6 |
Observational effect estimate outside the RCT 95% CI | 27/74 | 36.5 | 11/29 | 37.9 | 25/65 | 38.5 |
Statistically significant difference | 15/74 | 20.3 | 7/29 | 24.1 | 14/65 | 21.5 |
Statistically significant difference and effect estimates of observational studies and RCTs in opposite directions | 13/74 | 17.6 | 6/29 | 20.7 | 12/65 | 18.5 |