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Table 3 Univariable meta-regression

From: Is transcranial direct current stimulation, alone or in combination with antidepressant medications or psychotherapies, effective in treating major depressive disorder? A systematic review and meta-analysis

 

Response rate

Remission rate

 

Coef (B)

95% CI

p

Coef (B)

95% CI

p

Clinical characteristics

 Publication year

− 0.12

− 0.18 to 0.16

0.873

− 0.05

− 0.29 to 0.18

0.629

 Baseline score a

− 0.06

− 0.18 to 0.05

0.232

− 0.07

− 0.20 to 0.7

0.279

 Treatment strategy

  Monotherapy

− 1.09

− 2.31 to 0.13

0.075

− 0.58

− 2.66 to 1.49

0.536

  tDCS +medication

0.95

− 0.08 to 1.99

0.068

0.49

− 1.04 to 2.01

0.489

  tDCS +psychotherapy

− 0.799

− 2.07 to 0.47

0.189

− 0.44

− 2.43 to 1.55

0.624

Demographics

 Sample size

− 0.01

− 0.04 to 0.01

0.304

− 0.02

− 0.06 to 0.02

0.258

 Age

− 0.04

− 0.12 to 0.05

0.359

− 0.05

− 0.17 to 0.08

0.422

 Female rate

2.69

− 0.82 to 6.19

0.119

1.99

− 3.18 to 7.16

0.407

Montage parameters

 Size of electrode

− 0.06

− 0.14 to 0.02

0.114

− 0.01

− 0.11 to 0.10

0.912

 Current intensity

− 0.73

− 1.48 to 0.02

0.057

− 0.74

− 1.68 to 0.21

0.111

 Stimulation duration

− 0.19

− 0.14 to 0.1

0.723

− 0.07

− 0.23 to 0.09

0.335

 Number of sessions

− 0.11

− 0.24 to 0.02

0.090

− 0.21

− 0.42 to 0.01

0.060

 Total charge b

− 0.03

− 0.07 to 0.00

0.080

− 0.06

− 0.12 to − 0.00

0.040

  1. aBaseline score was calculated by the weighted arithmetic mean of depression scores of active and sham groups
  2. bTotal charge = (current intensity × stimulation duration × number of sessions)/size of electrode; boldface means q < 0.1