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Table 1 Summary information of 14 psychiatric disorders analyzed in this study

From: A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics

Traits

N (case/control)

m

S

λ

Inter

h2 (se)

Reference

AD

17,526 (5761/11,765)

5,479,241

22,720

1.032

1.008

0.050 (0.025)

[70]

ADHD

53,293 (19,099/34,194)

6,414,003

22,583

1.213

1.043

0.191 (0.012)

[80]

AN

14,477 (3495/10,982)

6,639,324

22,610

1.219

1.056

0.124 (0.009)

[69]

ASD

46,350 (18,381/27,969)

7,076,650

22,783

1.132

1.013

0.141 (0.010)

[71]

BIP

51,710 (20,352/31,358)

7,479,414

23,031

1.143

1.017

0.288 (0.012)

[74]

CU

184,765 (53,180/131,585)

6,908,164

22,758

1.105

1.012

0.056 (0.003)

[78]

MDD

480,359 (135,458/344,901)

5,372,902

16,595

1.153

1.019

0.062 (0.003)

[79]

OCD

9725 (2688/7037)

7,138,930

22,645

1.237

1.004

0.252 (0.040)

[73]

PTSD

174,659 (23,212/151,447)

7,482,865

22,762

1.152

1.005

0.004 (0.002)

[76]

SCZ

77,096 (33,640/43,456)

7,684,282

23,135

1.030

0.985

0.357 (0.012)

[75]

TS

14,307 (4819/9488)

7,120,803

22,608

1.065

1.059

0.297 (0.032)

[77]

AUDIT-T

121,604

7,790,148

22,995

1.441

1.060

0.065 (0.004)

[72]

AUDIT-C

121,604

7,790,148

22,948

1.088

1.005

0.059 (0.004)

[72]

AUDIT-P

121,604

7,790,148

22,883

1.175

0.998

0.044 (0.004)

[72]

  1. Note: N is the sample size of original GWASs; m is the number of SNPs used in MAGMA; S is the number of analyzed genes in MAGMA; λ is the genomic inflation factor estimated by LDSC; inter denotes the LDSC intercept; h2 is the SNP-based heritability estimated by LDSC. AD anxiety traits, ADHD attention-deficit/hyperactivity trait, AN anorexia nervosa, ASD autism spectrum trait, AUDIT-T alcohol use traits identification test based on total score, AUDIT-C alcohol use traits identification test based on consumption, AUDIT-P alcohol use traits identification test based on problematic consequences of drinking, BIP bipolar trait, CU cannabis use, MDD major depression trait, OCD obsessive-compulsive disorder, PTSD posttraumatic stress trait, SCZ schizophrenia, TS Tourette’s syndrome