Fig. 1

Identification of the common DMRs among BTCs in the EHSH cohort. A Diagram of the identification process. B Volcano plot illustrating the P value and β value difference of the 3369 DMRs. C The β value difference of the hypomethylation DMRs and their inner-correlations among iCCAs, pCCAs, dCCAs, and GBCs. D The β value difference of the hypermethylation DMRs and their inner-correlations among iCCAs, pCCAs, dCCAs, and GBCs. E Sankey plot of the hypomethylation and the hypermethylation DMRs. F, G Gene Ontology enrichment analyses of the hypomethylation- (F) and the hypermethylation-associated genes (G). BTC, biliary tract cancer; i/p/dCCA, intrahepatic/perihilar/distal cholangiocarcinoma; DMR, differentially methylated region; GBC, gallbladder cancer; GO, Gene Ontology