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Fig. 5 | BMC Medicine

Fig. 5

From: Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank

Fig. 5

Phenome-wide associations between obesity PRS and disease outcomes and interactions between obesity PRS and obesity lifestyle risk index on disease outcomes. Disease outcomes were limited to 40 significant findings from obesity PRS PheWAS. Disease outcomes are color-coded by their corresponding disease groups as described in the shared legend. PheWAS association models were adjusted for age, sex, genotyping array, and 5 PCs of ancestry. PheWAS association results are presented as OR (95%) and corresponding P value comparing highest (Q10) to lowest (Q1 - reference) decile of the obesity PRS. In interaction analyses, an interaction term between the PRS and the index was added and both the PRS and the index were added as covariates. Pint value are P values for the interaction term between the continuous PRS and obesity lifestyle risk index. Interactions were considered significant at Pint < 0.00125 accounting for 40 tests. Abbreviations: odds ratio (OR), phenome-wide association study (PheWAS), polygenic risk score (PRS), quartile (Q)

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