Table 1 Patient characteristics of the study population
From: Cell-free DNA methylation markers for differential diagnosis of hepatocellular carcinoma
| Â | HCC | Cirrhosis | Healthy Individuals | ||||||
|---|---|---|---|---|---|---|---|---|---|
Training | Validation | P value | Training | Validation | P value | Training | Validation | P value | |
Total, n | 120 | 67 | Â | 92 | 111 | Â | 290 | 242 | Â |
Age, years | |||||||||
 Mean ± SD | 53(24-83) | 54(23-74) | 0.599 | 48(26-81) | 52(22-82) | 0.005 | 50(21-89) | 50(18-79) | 0.633 |
AFP, ng/ml# | |||||||||
 Negative, ≤20 ng/ml | 41 | 20 | 0.869 | 53 | 65 | 0.617 | 83 | 63 |  |
 Positive, >20 ng/ml | 77 | 42 | 21 | 32 | 0 | 0 |  | ||
 UNK | 2 | 5 |  | 18 | 14 |  | 207 | 176 |  |
Gender | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Male | 106 | 55 | 0.273 | 74 | 89 | 0.86 | 236 | 192 | 0.584 |
 Female | 14 | 12 | 17 | 22 | 54 | 50 | |||
 UNK |  |  |  | 1 |  |  |  |  |  |
HBV infection* | |||||||||
 No | 11 | 9 | 0.461 | 22 | 9 | 0.003 | 60 | 54 | 0.896 |
 Yes | 105 | 57 | 67 | 98 | 65 | 56 | |||
 UNK | 4 | 1 |  | 3 | 4 |  | 165 | 132 |  |
Child-Pugh class | |||||||||
 A | 102 | 54 | 0.491 | 14 | 39 | 0.004 |  |  |  |
 B | 15 | 9 | 33 | 37 |  |  | |||
 C | 1 | 2 | 44 | 35 |  |  |  | ||
 UNK | 2 | 2 |  | 1 |  |  |  |  |  |
BCLC stage | |||||||||
 0 | 7 | 3 | 0.698 |  |  |  |  |  |  |
 A | 65 | 34 |  |  |  |  |  | ||
 B | 18 | 8 |  |  |  |  |  | ||
 C | 27 | 18 |  |  |  |  |  |  | |
 D | 3 | 4 |  |  |  |  |  |  | |