Skip to main content

Table 3 Effects of a rapid test for GBS on neonatal exposure to antibiotics compared to usual care

From: Rapid intrapartum test for maternal group B streptococcal colonisation and its effect on antibiotic use in labouring women with risk factors for early-onset neonatal infection (GBS2): cluster randomised trial with nested test accuracy study

Outcome

Rapid test, n (%)

Usual care, n (%)

Adjusted risk difference (95% CI)1

Adjusted relative risk (95% CI)2

Neonatal (live births only)

(n = 748)

(n = 947)

  

Antibiotics for any indication

    

 Yes

244 (33%)

412 (44%)

− 0.13 (− 0.23, − 0.02)

0.71 (0.54, 0.95)

 No

493 (67%)

534 (56%)

 Missing

11

1

  

Antibiotics for suspected early-onset sepsis

    

 Yes

187 (25%)

374 (39%)

− 0.15 (− 0.26, − 0.04)

0.63 (0.43,0.92)

 No

548 (75%)

572 (61%)

 Missing

13

1

  

Neonatal mortality (all neonates)*

(n = 749)

(n = 951)

  

 Yes

3 (0.4%)

8 (0.84%)

 

0.48 (0.10, 2.21)

 No

746 (99.6%)

943 (99.16%)

 Missing

0

0

  
  1. *Relative risk estimated from an unadjusted Poisson mixed effects model with robust standard errors, no model for the risk difference converged
  2. 1Risk difference; estimates < 0 favour rapid test
  3. 2Relative risk; estimates < 1 favour rapid test. Analyses adjusted for cluster size, unit birth rate, and estimated pre-trial IAP rates