Table 1 Baseline characteristics for three cohorts

Age (median)

52 (range 30, 76)

51 (range 23, 69)

55 (range 40, 71)

Sex (%)

 Male

 Female

6 (30%)

14 (70%)

16 (50%)

16 (50%

9 (69.2%)

4 (30.8%)

ECOG (%)

 0–1

 ≥ 2

14 (70%)

6 (30%)

22 (68.7%)

10 (31.3%)

9 (69.2%)

4 (30.8%)

Smoking status (%)

 Never smoker

 Current or former smoker

16 (80%)

4 (20%)

23 (71.9%)

9 (28.1%)

5 (38.5%)

8 (61.5%)

Pathology (%)

 Adenocarcinoma

 Other type

19 (95%)

1 (5%)

31 (96.9%)

1 (3.1%)

13 (100%)

0 (0%)

Stage (%)

 IV

 Recurrence after surgery or radical radiation

11 (55%)

9 (45%)

21 (65.6%)

11 (34.4%)

10 (76.9%)

3 (23.1%)

Previous brain radiotherapy or surgery (%)

 Yes

 No

5 (25%)

15 (75%)

6 (18.7%)

26 (81.3%)

2 (15.4%)

11 (84.6%)

Uncontrolled CNS metastases (%)

 Yes

 No

19 (95%)

1 (5%)

30 (93.7%)

2 (6.3%)

12 (92.3%)

1 (7.7%)

Leptomeningeal metastases (%)

 Yes

 No

4 (20%)

16 (80%)

2 (6.3%)

30 (93.7%)

3 (23.1%)

10 (76.9%)

With CNS target lesion (%)

Without CNS target lesion (%)

11 (55%)

9 (45%)

17 (53.1%)

15 (46.9%)

7 (53.8%)

6 (46.2%)

Median sums of maximum diameter in CNS target lesion

2.7 cm (range 1 cm, 5.3 cm)

2.4 cm (range 1.2 cm, 5.1 cm)

1.7 cm (range 1 cm, 3.2 cm)

Symptoms related to CNS lesion (%)

 Yes

 No

8 (40%)

12 (60%)

14 (43.7%)

18 (56.3%)

6 (46.2%)

7 (53.8%)

With extracranial lesion (%)

12 (60%)

29 (90.6%)

12 (92.3%)

Without extracranial lesion (%)

8 (40%)

3 (9.4%)

1 (7.7%)

With extracranial target lesion (%)

11 (55%)

12 (37.5%)

6 (46.2%)

Without extracranial target lesion (%)

9 (45%)

20 (62.5%)

7 (53.8%)