Fig. 2

FGF23 induces prolonged ventricular repolarization in healthy mice. A ECG waveforms in wild-type healthy mice before (black line) and after (red line) FGF23 administration (40 μg/kg). B–F Time course of QRS interval (B), QT interval (C), QTc interval (D), JT interval (E), and T peak to T end (TpTe) interval (F) measures from ECG recordings after vehicle (N = 5 mice) or FGF23 (N = 9 mice) administration. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001 versus baseline