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Fig. 5 | BMC Medicine

Fig. 5

From: The anti-aging factor Klotho protects against acquired long QT syndrome induced by uremia and promoted by fibroblast growth factor 23

Fig. 5

Klotho prevents Kv4.2 α-subunit downregulation in ventricular myocytes from Nfx and after FGF23 incubation. A mRNA expression of Kv4.2 channel subunit in Sham (N = 9 mice), Nfx (N = 8 mice), Sham+rKL (N = 9 mice), and Nfx+rKL (N = 7 mice) mice. B mRNA expression of Kv4.2 in neonatal ventricular cardiomyocytes incubated with vehicle (N = 6 replicate wells), FGF23 (N = 9 replicate wells), rKL (N = 9 replicate wells), and FGF23 + rKL (N = 11 replicate wells). Data are presented as mean ± SEM. *P < 0.05 vs. the corresponding control (Sham or vehicle-neonatal cardiomyocytes) and #P < 0.05 vs. FGF23-neonatal cardiomyocytes

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BMC Medicine

ISSN: 1741-7015

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