The anti-aging factor Klotho protects against acquired long QT syndrome induced by uremia and promoted by fibroblast growth factor 23

Table 2 Macroscopic and biochemical parameters in the experimental CKD model and after treatment with recombinant Klotho

	Sham	Nfx	Sham+rKL	Nfx + rKL
Macroscopic parameters
Body weight (BW, g)	27.7 ± 0.6	25.0 ± 0.8	26.2 ± 0.7	25.3 ± 0.8
Heart weight (HW, mg)	206.7 ± 10.9	178.6 ± 12.4	181.0 ± 4.2	192.4 ± 7.7
HW/BW	7.7 ± 0.2	7.8 ± 0.2	7.2 ± 0.2	7.5 ± 0.3
Cardiomyocyte area (a.u.²)	3406 ± 123	3380 ± 146	2958 ± 141	3123 ± 128
Kidney weight (mg)	164.4 ± 0.5	142.7 ± 0.7	153.6 ± 0.3	133.1 ± 0.9
Biochemical parameters
Urea (mg/dL)	51.7 ± 3.0	112.7 ± 11.1***	42.1 ± 3.9	109.4 ± 11.4^†††
BUN (mg/dL)	24.2 ± 1.4	52.7 ± 5.2***	19.7 ± 1.8	51.1 ± 5.3^†††
Phosphorus (mg/dL)	8.3 ± 1.0	7.6 ± 0.8	6.3 ± 0.9	8.2 ± 0.9
FGF23 (pg/mL)	148.9 ± 15.9	345.4 ± 54.2**	123.0 ± 12.0	353.1 ± 49.7^†††

Data from 8 animals for macroscopic and biochemical parameters per experimental group are reported as mean ± SEM. BW, body weight; HW heart weight; BUN blood urea nitrogen; FGF23, fibroblast growth factor 23. **P < 0.01, ***P < 0.001 vs. Sham; ^†††P < 0.001 vs. Sham+rKL. Sham and Nfx mice were treated with vehicle solution (0.9% sodium chloride)

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