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Fig. 4 | BMC Medicine

Fig. 4

From: Triggering anti-GBM immune response with EGFR-mediated photoimmunotherapy

Fig. 4

Early efficacy assessment using an MRI-based approach. A Coronal and axial T2-weighted, coronal T2*-weighted images (TE, 12 ms), and corresponding R2* maps in animals before and after 100 J/cm2 irradiation. Haemorrhagic areas can be seen 1 h after PIT on both T2-weighted and T2*-weighted images. Note the presence of cerebral oedema (yellow arrows). Blue arrows point out the tumour and peritumoural oedema. B Quantification of the R2* parameter in mice from the control group (100 J/cm2 light irradiation only, n = 3), 1 h (18 μg of ZEGFR:03115-IR700 + 100 J/cm2, n = 3) and 4 h post-PIT (18 μg of ZEGFR:03115-IR700 + 100 J/cm2, n = 2). Bars represent the % change of median R2* parameters from the baseline measured on ROIs drawn onto the tumours at TE = 3. C Table presenting the R2* values (s−1) of each mouse pre- and post-PIT with their corresponding % change from the baseline. R2* values from mice presented on the images are encircled with blue dashed lines

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