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Table 3 Multivariable-adjusted hazard ratios for liver-related and all-cause mortality associated with elevated alanine aminotransferase (ALT) levels by alcohol intake status

From: Modest alcohol intake and mortality in individuals with elevated alanine aminotransferase levels: a nationwide cohort study

Alcohol intake

Alanine aminotransferasea

p for interaction

Normal

HR (95% CI)

Elevated

HR (95% CI)

Liver-related mortality

<  0.01

 None

Reference

2.84 (2.12, 3.80)

 

 Light

Reference

6.10 (4.03, 9.24)

 

 Moderate

Reference

5.63 (3.79, 8.34)

 

All-cause mortality

<  0.01

 None

Reference

0.97 (0.90, 1.04)

 

 Light

Reference

1.26 (1.10, 1.45)

 

 Moderate

Reference

1.41 (1.24, 1.61)

 
  1. HRs and 95% CIs were obtained from proportional hazards models with age as time scale and adjusted for sex, body mass index, Charlson comorbidity index, diabetes, hypertension, hyperlipidemia, smoking status (never, ever or unknown), residential area (metropolitan, rural and unknown) and income percentile (≤30th, >30th–≤70th, >70th, and unknown)
  2. Abbreviation: HR, hazard ratio; CI, confidence interval
  3. aNormal: < 34 U/L for men and <25 U/L for women; elevated: ≥34 U/L for men and ≥25 U/L for women