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Fig. 3 | BMC Medicine

Fig. 3

From: Exploring the causal effect of maternal pregnancy adiposity on offspring adiposity: Mendelian randomisation using polygenic risk scores

Fig. 3

Mean difference in offspring BW and BMI (SD) per 1SD increase in maternal BMI, from MR models using different SNP sets and confounder adjusted multivariable regression (MV) models. Confounder adjusted multivariable regression (MV) estimates are from model three (see the “Methods” section). N, number of participants. The number of SNPs used for the MR analyses is provided separately by cohort in Table 1. P, P-value for the null hypothesis that the effect equals zero; Pdif, P-value for the null hypothesis that MR effect equals the MV effect; FTO, rs9939609 at the FTO locus; Speliotes, Locke, Yengo, GWS SNPs from the GWAS with the indicated first author; Lassosum, PRS calculated by the lassosum method. Colours denote outcomes

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