Table 2 Linear regression results between newborn telomere length and significant factors using all, male-only, and female-only subjects
From: Variability in newborn telomere length is explained by inheritance and intrauterine environment
Variable | Multivariate model (adjusted for sex and ethnicity), all | Multivariate model (adjusted for ethnicity), male | Multivariate model (adjusted for ethnicity), female | ||||||
|---|---|---|---|---|---|---|---|---|---|
N | β (95%CI) | P value | N | β (95%CI) | P value | N | β (95%CI) | P value | |
Maternal telomere length (T/S) | 892 | 0.14 (0.08, 0.20) | 1.99E−05** | 465 | 0.11 (0.02, 0.2) | 1.67E−02* | 427 | 0.17 (0.08, 0.26) | 3.09E−04** |
Paternal age (years) | 805 | 0.10 (0.03, 0.17) | 3.73E−03* | 427 | 0.13 (0.04, 0.22) | 3.53E−03* | 378 | 0.06 (− 0.05, 0.16) | 2.83E−01 |
Maternal age (years) | 950 | 0.07 (0.01, 0.14) | 2.78E−02* | 500 | 0.11 (0.02, 0.20) | 1.60E−02* | 450 | 0.03 (− 0.06, 0.12) | 5.36E−01 |
EPDS | 918 | − 0.05 (− 0.11, 0.02) | 1.40E−01 | 484 | − 0.01 (− 0.1, 0.07) | 7.77E−01 | 434 | − 0.10 (− 0.19, 0.00) | 4.23E−02* |
STAI State Score | 895 | − 0.07 (− 0.14, − 0.01) | 2.93E−02* | 470 | − 0.02 (− 0.11, 0.08) | 7.37E−01 | 425 | − 0.13 (− 0.22, − 0.04) | 3.79E−03* |
STAI Trait Score | 891 | − 0.09 (− 0.16, − 0.03) | 3.61E−03* | 468 | − 0.05 (− 0.15, 0.04) | 2.54E−01 | 423 | − 0.14 (− 0.22, − 0.05) | 2.22E−03* |
Plasma fasting glucose (mmol/L) | 905 | − 0.08 (− 0.14, − 0.01) | 1.60E−02* | 476 | − 0.12 (− 0.22, − 0.02) | 1.39E−02* | 429 | − 0.04 (− 0.13, 0.04) | 3.21E−01 |
Plasma DGLA% | 831 | − 0.03 (− 0.09, 0.04) | 4.65E−01 | 432 | − 0.11 (− 0.22, − 0.01) | 3.04E−02* | 399 | 0.04 (− 0.05, 0.13) | 3.28E−01 |
Plasma IGFBP3 (ng/mL), log10 | 938 | − 0.08 (− 0.15, − 0.02) | 7.62E−03* | 493 | − 0.15 (− 0.23, − 0.06) | 8.29E−04** | 445 | − 0.02 (− 0.11, 0.07) | 7.09E−01 |
Plasma vitamin B12 (pg/mL), log10 | 834 | 0.08 (0.01, 0.14) | 2.87E−02* | 435 | 0.05 (− 0.04, 0.15) | 2.80E−01 | 399 | 0.09 (0.00, 0.19) | 5.39E−02 |
Maternal education | |||||||||
 1: Secondary and below | 283 | 0.07 (− 0.01, 0.16) | 7.79E−02 | 154 | 0.11 (0.00, 0.23) | 5.28E−02 | 129 | 0.03 (− 0.09, 0.15) | 6.55E−01 |
 2: Post-secondary | 336 | 172 | 164 | ||||||
 3: University | 319 | 166 | 153 | ||||||
Maternal Smoking during Pregnancy | |||||||||
 0: no | 788 | − 0.35 (− 0.67, − 0.03) | 3.06E−02* | – | – | – | – | – | – |
 1: yes | 39 | ||||||||