Table 3 The contributing factors that best explained newborn telomere length using all, male-only, and female-only subjects by model selection method. In each multivariate model, the factors were analyzed simultaneously for comparing their contributions to variation in newborn telomere length
From: Variability in newborn telomere length is explained by inheritance and intrauterine environment
Variable | All (N = 721) | Male (N = 378) | Female (N = 405) | |||
|---|---|---|---|---|---|---|
β (95%CI) | P value | β (95%CI) | P value | β (95%CI) | P value | |
Sex | ||||||
 Male | Ref | Ref | – | – | – | – |
 Female | 0.44 (0.30,0.58) | 7.42E−10*** | ||||
Ethnicity | ||||||
 Chinese | Ref | Ref | Ref | Ref | Ref | Ref |
 Malay | − 0.17 (− 0.34, 0.00) | 5.65E−02 | − 0.10 (− 0.32, 0.13) | 4.01E−01 | − 0.33 (− 0.56, − 0.11) | 4.16E−03* |
 Indian | − 0.22 (− 0.43, − 0.01) | 3.73E−02* | − 0.20 (− 0.50, 0.09) | 1.83E−01 | − 0.21 (− 0.48,0.05) | 1.19E−01 |
Newborn LRRC34- rs10936600 (0-AA 1-AT 2-TT) | − 0.20 (− 0.30, − 0.10) | 1.70E−04** | − 0.23 (− 0.37, − 0.09) | 1.53E−03* | − 0.15 (− 0.28,− 0.02) | 2.86E−02* |
Maternal telomere length (T/S) | 0.12 (0.05, 0.19) | 4.92E−04** | 0.11 (0.01, 0.21) | 3.16E−02* | 0.16 (0.07, 0.25) | 5.37E−04** |
Paternal age (years) | 0.13 (0.06, 0.20) | 2.16E−04** | 0.20 (0.10, 0.29) | 3.43E−05** | – | – |
Plasma fasting glucose (mmol/L) | − 0.08 (− 0.14, − 0.01) | 2.42E−02* | − 0.15 (− 0.24, − 0.05) | 3.91E−03* | – | – |
Plasma IGFBP3 (ng/mL), log10 | − 0.08 (− 0.15, − 0.02) | 1.45E−02* | − 0.18 (− 0.27, − 0.09) | 1.41E−04** | – | – |
STAI Trait Score | – | – | – | – | − 0.13 (− 0.22, − 0.04) | 4.12E−03* |