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Table 2 Genetic characteristics of patients with HFpEF in HCM

From: Identification of heart failure with preserved ejection fraction helps risk stratification for hypertrophic cardiomyopathy

Genetics All (n=946) HFpEF# (n=415) Non-HF# (n=531) P value*
Mutation-positive 313 (33.1) 152 (36.6) 161 (30.3) 0.041
Multiple variants 6 (0.6) 4 (1.0) 2 (0.4) 0.413
MYH7 151 (16.0) 74 (17.8) 77 (14.5) 0.165
MYBPC3 127 (13.4) 56 (13.5) 71 (13.4) 0.956
ACTC1 0 (0.0) 0 (0.0) 0 (0.0) -
MYL2 6 (0.6) 4 (1.0) 2 (0.4) 0.413
MYL3 4 (0.4) 3 (0.7) 1 (0.2) 0.325
TNNI3 16 (1.7) 8 (1.9) 8 (1.5) 0.618
TNNT2 13 (1.4) 9 (2.2) 4 (0.8) 0.064
TPM1 2 (0.2) 1 (0.2) 1 (0.2) 1.000
  1. AHA American Heart Association, HCM hypertrophic cardiomyopathy, HFpEF heart failure with preserved ejection fraction, non-HF patients without heart failure
  2. #Heart failure phenotypes were identified using AHA criteria
  3. *Comparison between patients with HFpEF and non-HF patients