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Table 2 Genetic characteristics of patients with HFpEF in HCM

From: Identification of heart failure with preserved ejection fraction helps risk stratification for hypertrophic cardiomyopathy

Genetics

All (n=946)

HFpEF# (n=415)

Non-HF# (n=531)

P value*

Mutation-positive

313 (33.1)

152 (36.6)

161 (30.3)

0.041

Multiple variants

6 (0.6)

4 (1.0)

2 (0.4)

0.413

MYH7

151 (16.0)

74 (17.8)

77 (14.5)

0.165

MYBPC3

127 (13.4)

56 (13.5)

71 (13.4)

0.956

ACTC1

0 (0.0)

0 (0.0)

0 (0.0)

-

MYL2

6 (0.6)

4 (1.0)

2 (0.4)

0.413

MYL3

4 (0.4)

3 (0.7)

1 (0.2)

0.325

TNNI3

16 (1.7)

8 (1.9)

8 (1.5)

0.618

TNNT2

13 (1.4)

9 (2.2)

4 (0.8)

0.064

TPM1

2 (0.2)

1 (0.2)

1 (0.2)

1.000

  1. AHA American Heart Association, HCM hypertrophic cardiomyopathy, HFpEF heart failure with preserved ejection fraction, non-HF patients without heart failure
  2. #Heart failure phenotypes were identified using AHA criteria
  3. *Comparison between patients with HFpEF and non-HF patients