Skip to main content

Table 3 Change in HbA1c values (with HbA1c denoted in mmol/mol) after metformin titration

From: The effect of oral diabetes medications on glycated haemoglobin (HbA1c) in Asians in primary care: a retrospective cohort real-world data study

Metformin dose after titration

0

125

250

500

750

850

1000

1500

1700

2000

2250

2550

3000

  

-3(-4, -3)#m=487

-7(-7, -7)#m=1849

  

-10(-11, -9)#m=676

-8(-12, -3)#m=36

-7(-11, -3)#m=60

    
  

-4(-7, -2)#m=34

          

6(4, 8)#m=173

2(1, 3)#m=105

 

-4(-6, -4)#m=906

  

-10(-13, -8)#m=87

      

6(4, 8)#m=220

 

3(3, 4)#m=1412

 

-3(-4, -2)#m=282

 

-7(-7, -7)#m=3108

-9(-12, -6)#m=77

-14(-18, -11)#m=53

    
   

2(1, 3)#m=182

  

-3(-4, -2)#m=225

-7(-9, -6)#m=190

-8(-12, -4)#m=31

    
   

3(-0, 6)#m=34

  

1(-1, 3)#m=58

 

-3(-6, -2)#m=161

  

-2(-6, 0)#m=39

 

8(4, 10)#m=137

 

8(3, 12)#m=31

6(4, 6)#m=1953

-1(-2, 0)#m=105

-1(-3, 0)#m=57

 

-4(-6, -5)#m=2150

-7(-7, -6)#m=1670

-4(-7, -3)#m=198

 

-10(-14, -7)#m=47

-6(-8, -2)#m=47

12(7, 16)#m=41

  

8(5, 11)#m=96

3(1, 6)#m=91

 

4(3, 4)#m=1128

 

-3(-3, -2)#m=739

-4(-6, -3)#m=418

-7(-7, 6)#m=498

-8(-9, -7)#m=398

 

13(8, 19)#m=46

  

8(3, 12)#m=38

 

2(1, 3)#m=240

6(6, 7)#m=773

1(0, 2)#m=142

 

-2(-3, -2)#m=611

 

-6(-6, -4)#m=1154

 
      

4(3, 6)#m=228

3(1, 6)#m=82

3(1, 4)#m=127

  

-3(-4, -2)#m=179

-3(-6, -2)#m=458

      

6(2, 9)#m=34

3(3, 4)#m=227

1(-2, 3)#m=30

1(-2, 3)#m=42

 

-4(-4, -3)#m=311

-4(-7, -2)#m=124

     

3(0, 7)#m=30

6(3, 9)#m=75

6(4, 7)#m=165

3(3, 4)#m=920

-1(-2, 0)#m=182

3(-0, 6)#m=33

 

-3(-4, -2)#m=642

      

10(6, 14)#m=41

9(6, 11)#m=65

 

4(3, 4)#m=438

4(2, 7)#m=35

2(0, 3)#m=129

 
  1. Change in HbA1c values after metformin initiation, titration, or discontinuation. The values above the diagonal represent the instances where the medication has been initiated or up-titrated, while the values below the diagonal represent instances where the medication has been down-titrated or discontinued. The values refer to the mean difference in HbA1c (MD) and 95% confidence intervals. MD below 0 indicate a lowering in HbA1c while those above 0 indicate an increase in HbA1c. #m refers to the number of HbA1c pairs for that dose titration