The effect of oral diabetes medications on glycated haemoglobin (HbA1c) in Asians in primary care: a retrospective cohort real-world data study

Table 4 Change in HbA1c values (with HbA1c denoted in mmol/mol) after glipizide titration

Glipizide dose after titration
0	2.5	5	7.5	10	12.5	15	20	25	30	40
	-8(-9, -7)#m=471	-11(-12, -10)#m=1283		-13(-14, -11)#m=364			-1(-7, 3)#m=41
8(8, 9)#m=596		-6(-6, -4)#m=660		-9(-14, -3)#m=51
10(10, 11)#m=818	4(3, 4)#m=815		-4(-7, -1)#m=82	-3(-3, -2)#m=1686
		2(0, 6)#m=59		-0(-2, 1)#m=157		-0(-1, 1)#m=133
10(9, 12)#m=260	3(1, 6)#m=32	3(3, 3)#m=1042	0(-1, 1)#m=267			-2(-2, -1)#m=966	-2(-3, -2)#m=753
								0(-2, 2)#m=57
		1(-1, 3)#m=30	1(0, 3)#m=50	2(1, 3)#m=376			-1(-1, 0)#m=852		-1(-2, 1)#m=294
10(6, 13)#m=47				2(2, 3)#m=514	-1(-2, 0)#m=145	0(0, 1)#m=362		-2(-3, -1)#m=617	-1(-2, 0)#m=465
						0(-2, 2)#m=72	1(-1, 2)#m=95		-1(-2, 0)#m=444
7(2, 10)#m=45				2(-1, 4)#m=68		3(2, 4)#m=259	3(2, 4)#m=323	2(0, 3)#m=83		-3(-6, 0)#m=73

Change in HbA1c values after glipizide initiation, titration or discontinuation. The values above the diagonal represent the instances where the medication has been initiated or up-titrated, while the values below the diagonal represent instances where the medication has been down-titrated or discontinued. The values refer to the mean difference in HbA1c (MD) and 95% confidence intervals. MD below 0 indicate a lowering in HbA1c while those above 0 indicate an increase in HbA1c. #m refers to the number of HbA1c pairs for that dose titration

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