Tolbutamide dose after titration |
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0 | 250 | 500 | 750 | 1000 | 1500 | 2000 | 2250 | 3000 |
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| -8(-11, -6)#m=52 | -12(-14, -9)#m=103 | | | | | | |
6(3, 7)#m=90 | | -6(-8, -3)#m=92 | | | | | | |
7(6, 8)#m=177 | 3(2, 4)#m=243 | | -3(-7, 0)#m=44 | -6(-7, -4)#m=203 | | | | |
| | 1(-1, 2)#m=89 | | 1(-3, 6)#m=37 | -6(-8, -2)#m=52 | | | |
8(3, 11)#m=45 | | 4(3, 4)#m=277 | | | -3(-6, -2)#m=187 | | | |
| | | 3(2, 6)#m=64 | 1(0, 2)#m=190 | | -1(-4, 2)#m=42 | -6(-8, -3)#m=96 | |
| | | | 7(3, 11)#m=50 | | | | -7(-11, -3)#m=42 |
| | | | | 4(3, 6)#m=95 | | | -4(-7, -2)#m=62 |
| | | | | 6(2, 9)#m=43 | 3(2, 6)#m=67 | | |
- Change in HbA1c values after tolbutamide initiation, titration, or discontinuation. The values above the diagonal represent the instances where the medication has been initiated or up-titrated, while the values below the diagonal represent instances where the medication has been down-titrated or discontinued. The values refer to the mean difference in HbA1c (MD) and 95% confidence intervals. MD below 0 indicate a lowering in HbA1c while those above 0 indicate an increase in HbA1c. #m refers to the number of HbA1c pairs for that dose titration