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Table 2 Details of included studies

From: Systematic review and meta-analysis of the diagnostic accuracy of prostate-specific antigen (PSA) for the detection of prostate cancer in symptomatic patients

First author

Year

Country

Number of patients

Mean age (range)*

Setting

PSA range

Stage/grade data

Reference test

Abdrabo et al. [15]

2011

Sudan

118

70 years (56–83)

One hospital urology clinic

2.5–10 ng/mL

No

TRUS biopsy

Agnihotri et al. [16]

2014

India

875 biopsied (of 4702 patients)

66 years (50–75)

One hospital urology clinic

Any

No

TRUS biopsy

Aragona et al. [17]

2005

Italy

3171 biopsied (of 16,298 patients)

62 years (40–75)

15 hospital urology clinics

Any

Clinical TNM staging

TRUS biopsy

Chang et al. [18]

2015

Taiwan

225

PCa 72 years; BPH 67 years

One hospital urology clinic

Any

TNM stage and Gleason Score

TRUS biopsy

Chavan et al. [19]

2009

India

440 biopsied (of 922 patients)

64 years (40–95)

One tertiary hospital urology clinic

Any

No

TRUS biopsy

Galic et al. [20]

2003

Croatia

88 biopsied (of 944 patients)

≥ 50 years

Recruited from two villages to attend hospital clinic

Not stated

No

TRUS biopsy

Hofer et al. [21]

2000

Germany

188

PCa 70 years; BPH 68 years

One hospital urology clinic

Any

No

TRUS biopsy/TURP/non-cancer surgery

Lee et al. [22]

2006

Korea

201

63 years

One hospital urology clinic

< 4 ng/mL

No

TRUS biopsy

Magistro et al. [23]

2020

Germany

1125

70 years

One hospital urology clinic

Any

TNM stage and Gleason Score

HoLEP (+ mpMRI with targeted and systemic biopsy for some patients)

Meigs et al. [24]

1996

USA

1524

50-79 years

One hospital urology clinic + two BPH study cohorts

Any

Clinical T stage

TRUS biopsy/TURP/non-cancer surgery

Nordstrom et al. [25]

2021

Sweden

1554

64 years (50–69)

Population-based screening study cohort

> 3 ng/mL

TNM stage and Gleason Score

TRUS biopsy

Patel et al. [26]

2009

UK

647 biopsied (of 3976 patients)

65 years (15–91)

One hospital urology clinic

Any

No

TRUS biopsy

Pepe et al. [27]

2007

Italy

403 biopsied (of 13,294 patients)

62 years (40–75)

Two hospital urology clinics

< 4 ng/mL

Pathological T stage

TRUS biopsy

Rashid et al. [28]

2012

Bangladesh

206

> 50 years

One hospital urology clinic and one nursing home

> 2.5 ng/mL

No

TRUS biopsy

Richie et al. [29]

1993

USA

1167 biopsied (of 6630 patients)

63 years (50–96)

Six medical centres

Any

TNM stage and Gleason Score

TRUS biopsy

Seo et al. [30]

2007

Korea

4967

66 years (40–96)

25 hospital urology clinics

Any

No

TRUS biopsy

Shahab et al. [31]

2013

Indonesia

404

64 years (34–84)

One hospital urology clinic

Any

TNM stage and Gleason Score

TRUS biopsy

Tauro et al. [32]

2009

India

100

68 years

One hospital urology clinic

Any

No

TRUS biopsy

Wymenga et al. [33]

2000

The Netherlands

716

Not reported

Two hospital urology clinics

Any

Clinical T stage

TRUS biopsy/TURP/prostatectomy

  1. PSA prostate-specific antigen, TRUS transrectal ultrasound-guided biopsy, PCa prostate cancer, BPH benign prostatic hypertrophy, TNM tumour-node-metastasis, TURP transurethral resection of the prostate, HoLEP holmium laser enucleation of the prostate, mpMRI multiparametric magnetic resonance imaging
  2. *Age range and/or mean not present in table if not reported