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Table 2 Details of included studies

From: Systematic review and meta-analysis of the diagnostic accuracy of prostate-specific antigen (PSA) for the detection of prostate cancer in symptomatic patients

First author Year Country Number of patients Mean age (range)* Setting PSA range Stage/grade data Reference test
Abdrabo et al. [15] 2011 Sudan 118 70 years (56–83) One hospital urology clinic 2.5–10 ng/mL No TRUS biopsy
Agnihotri et al. [16] 2014 India 875 biopsied (of 4702 patients) 66 years (50–75) One hospital urology clinic Any No TRUS biopsy
Aragona et al. [17] 2005 Italy 3171 biopsied (of 16,298 patients) 62 years (40–75) 15 hospital urology clinics Any Clinical TNM staging TRUS biopsy
Chang et al. [18] 2015 Taiwan 225 PCa 72 years; BPH 67 years One hospital urology clinic Any TNM stage and Gleason Score TRUS biopsy
Chavan et al. [19] 2009 India 440 biopsied (of 922 patients) 64 years (40–95) One tertiary hospital urology clinic Any No TRUS biopsy
Galic et al. [20] 2003 Croatia 88 biopsied (of 944 patients) ≥ 50 years Recruited from two villages to attend hospital clinic Not stated No TRUS biopsy
Hofer et al. [21] 2000 Germany 188 PCa 70 years; BPH 68 years One hospital urology clinic Any No TRUS biopsy/TURP/non-cancer surgery
Lee et al. [22] 2006 Korea 201 63 years One hospital urology clinic < 4 ng/mL No TRUS biopsy
Magistro et al. [23] 2020 Germany 1125 70 years One hospital urology clinic Any TNM stage and Gleason Score HoLEP (+ mpMRI with targeted and systemic biopsy for some patients)
Meigs et al. [24] 1996 USA 1524 50-79 years One hospital urology clinic + two BPH study cohorts Any Clinical T stage TRUS biopsy/TURP/non-cancer surgery
Nordstrom et al. [25] 2021 Sweden 1554 64 years (50–69) Population-based screening study cohort > 3 ng/mL TNM stage and Gleason Score TRUS biopsy
Patel et al. [26] 2009 UK 647 biopsied (of 3976 patients) 65 years (15–91) One hospital urology clinic Any No TRUS biopsy
Pepe et al. [27] 2007 Italy 403 biopsied (of 13,294 patients) 62 years (40–75) Two hospital urology clinics < 4 ng/mL Pathological T stage TRUS biopsy
Rashid et al. [28] 2012 Bangladesh 206 > 50 years One hospital urology clinic and one nursing home > 2.5 ng/mL No TRUS biopsy
Richie et al. [29] 1993 USA 1167 biopsied (of 6630 patients) 63 years (50–96) Six medical centres Any TNM stage and Gleason Score TRUS biopsy
Seo et al. [30] 2007 Korea 4967 66 years (40–96) 25 hospital urology clinics Any No TRUS biopsy
Shahab et al. [31] 2013 Indonesia 404 64 years (34–84) One hospital urology clinic Any TNM stage and Gleason Score TRUS biopsy
Tauro et al. [32] 2009 India 100 68 years One hospital urology clinic Any No TRUS biopsy
Wymenga et al. [33] 2000 The Netherlands 716 Not reported Two hospital urology clinics Any Clinical T stage TRUS biopsy/TURP/prostatectomy
  1. PSA prostate-specific antigen, TRUS transrectal ultrasound-guided biopsy, PCa prostate cancer, BPH benign prostatic hypertrophy, TNM tumour-node-metastasis, TURP transurethral resection of the prostate, HoLEP holmium laser enucleation of the prostate, mpMRI multiparametric magnetic resonance imaging
  2. *Age range and/or mean not present in table if not reported